Endometrial integrin expression in women undergoing IVF and ICSI: a comparison of the two groups and fertile controls

Kerrie L. Thomas, Thomas K, K Thomas, A J Thomson, Thomson AJ, S J Wood, Wood SJ, Kingsland CR, C R Kingsland, G Vince, Vince G, D I Lewis-Jones, Lewis-Jones DI
Human Reproduction · 2003 · vol. 18(2) , pp. 364–369 · doi:10.1093/humrep/deg104 · PMID:12571175 · W2011628554
article OA: bronze CC0 ⤵ 3 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

Endometrial integrin expression during the implantation window did not differ between women undergoing IVF or ICSI and fertile controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: Integrins are thought to play a vital role in implantation. Three integrins in particular (alpha(4)beta(1), alpha(v)beta(3) and alpha(1)beta(1)) are all present during the implantation window. Defects in their expression have been linked to tubal disease, unexplained infertility and endometriosis. Hence, a reduced endometrial integrin expression would be expected in women attending for IVF due to these causes of infertility when compared with those with male factor infertility attending for ICSI. METHODS: Women attending for IVF (n = 25) and ICSI (n = 25) treatment were recruited, and timed endometrial biopsies were taken during the 'implantation window' (cycle day 20-24). A group of fertile women (n = 15) attending for sterilization was used as controls. RESULTS: There was no significant difference in integrin expression between patients undergoing IVF or ICSI. Neither did these groups differ from the control group. CONCLUSIONS: The endometrium in patients undergoing ICSI treatment is sometimes thought to be more receptive, as the infertility might be due to a male factor. This study shows that there is no significant difference in integrin expression between patients attending for IVF or ICSI and the control group. These data add to the increasing uncertainty about the clinical value of assessing the endometrium with only one marker, in this case integrins.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Endometrium Fertilization in Vitro Infertility, Female Infertility, Female Integrins Sperm Injections, Intracytoplasmic Adult Case-Control Studies Endometriosis Endometriosis Endometrium Fallopian Tube Diseases Fallopian Tube Diseases Female Humans Immunohistochemistry Immunohistochemistry Infertility, Female Infertility, Female Integrins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (3)

Source provenance

europepmc
last seen: 2026-09-14T06:17:53.580500+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:12:55.732728+00:00
License: CC0 · commercial use OK