Embryo Quality and Endometrial Receptivity: Lessons Learned from the ART Experience

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This review discusses the interplay between embryo quality and endometrial receptivity within the context of assisted reproductive technologies (ART).

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This paper discusses the interplay between embryo quality and endometrial receptivity as informed by the assisted reproductive technologies experience, with a synthesis of evidence on how endometrial maturity, timing (“window” of transfer), and implantation markers relate to conception efficiency and pregnancy loss. It highlights findings that uterine receptivity depends on factors such as endometrial asynchrony, integrin expression patterns, hormonal milieu, and embryonic development stage, and notes that aberrant receptivity markers and uterine conditions can impair implantation-related outcomes. A key caveat is that the evidence base spans studies with different designs, populations, and endpoints (including marker studies and IVF program analyses), limiting direct comparability across results. Relevance to endometriosis: the paper explicitly frames endometrial receptivity markers and implantation performance in the context of endometriosis, including cited work on impaired endometrial integrin expression and reduced cycle fecundity in an IVF program, though the overall paper focus is on embryo quality and receptivity lessons from ART.

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