Expression pattern of osteopontin and  v 3 integrin during the implantation window in infertile patients with early stages of endometriosis

Gemma Casals, Jaume Ordi, Jaume Ordï, Montse Creus, Montserrat Creus, Francisco Fábregues, Francisco Carmona, Roser Casamitjana, Juan Balasch, Joan Balasch
Human Reproduction · 2012 · vol. 27(3) , pp. 805–813 · doi:10.1093/humrep/der432 · PMID:22215628 · W2150680592
article OA: bronze CC0 ⤵ 20 in-corpus citations
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This study found no difference in osteopontin and αvβ3 integrin expression between infertile patients with early endometriosis and control groups during the implantation window.

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Abstract

BACKGROUND: To study endometrial receptivity in terms of osteopontin (OPN) and αvβ3 integrin expression and co-expression in infertile women with early stages of endometriosis. METHODS: We investigated the immunohistochemical expression and co-expression of OPN and αvβ3 integrin in the endometrium of 20 infertile patients with Stage I or II endometriosis as the only detectable cause of infertility, 20 infertile patients with unexplained infertility and 20 fertile women undergoing tubal sterilization. Two endometrial biopsies were performed during a single menstrual cycle (postovulatory Day +7 to +8 and 4 days later) in each subject. RESULTS: No statistically significant differences regarding OPN and αvβ3 integrin expression were found between infertile patients with endometriosis and the two control groups. There was no significant correlation between OPN and αvβ3 integrin staining intensity in the mid-luteal phase biopsies in any of the groups studied. CONCLUSIONS: Endometrial OPN and αvβ3 integrin expression or co-expression is not impaired during the window of implantation in patients with Stage I-II endometriosis. Further studies are needed to determine whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with these markers of implantation.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Embryo Implantation Endometriosis Endometrium Infertility, Female Integrin alphaVbeta3 Osteopontin Endometriosis Endometriosis Endometrium Female Humans Infertility, Female Infertility, Female Integrin alphaVbeta3 Osteopontin

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References (58)

Cited by (20)

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License: CC0 · commercial use OK