Expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 genes in eutopic endometrium of infertile women with endometriosis during the implantation window: a pilot study

Michele G Da Broi, Michele Gomes Da Broi, Carlos V Rocha, Juliana Meola, Wellington P Martins, Filomena Marino Carvalho, Filomena M Carvalho, Rui A Ferriani, Rui Alberto Ferriani, Paula A Navarro, Paula Andrea Navarro
JBRA assisted reproduction · 2017 · vol. 21(3) , pp. 196–202 · doi:10.5935/1518-0557.20170038 · PMID:28837027 · PMC5574640 · W2745949547
article OA: bronze CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This pilot study found no significant difference in the expression of PGR, HBEGF, ITGAV, ITGB3, and SPP1 genes in the endometrium of infertile women with endometriosis compared to control groups during the implantation window.

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Abstract

OBJECTIVE: Alterations in endometrial receptivity may be involved in the etiopathogenesis of endometriosis-related infertility. The literature has suggested that patients with endometriosis present progestin resistance, which could affect embryo implantation. We question the presence of alterations in the expression of the progesterone receptor gene (PGR) and the genes related to endometrium-embryo interaction regulated by progesterone. This pilot study compared the expression of PGR, HBEGF, ITGAV, ITGB3, and SPP1 genes in eutopic endometrium during the implantation window (IW) in infertile women with endometriosis with that observed in the endometrium of fertile and infertile controls. METHODS: In this prospective case-control study, endometrial biopsies were performed during the IW in patients aged between 18 and 45 years old, with regular cycles and without endocrine/systemic dysfunctions, divided into endometriosis (END), infertile control (IC) and fertile control (FC) groups. Total RNA extraction, cDNA synthesis, and gene expression analysis by Real-Time PCR were performed. We assessed the size of the difference that our series was powered to detect. RESULTS: From the 687 patients who underwent diagnostic videolaparoscopy or tubal ligation at the University Hospital, 130 were eligible. Of these, 32 had endometrial samples collected, with 17 confirmed in the IW. Fifteen samples (5 END, 5 IC and 5 FC) were analyzed. There was no significant difference in the expression of any studied gene. Our sample size allowed us to identify or discard large differences (two standard deviations) among the groups. CONCLUSION: Endometriosis doesn't cause large changes in the endometrial expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 during the IW.

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Condition tags

endometriosisinfertility

MeSH descriptors

Embryo Implantation Endometriosis Endometrium Infertility, Female Adult Endometriosis Endometriosis Endometriosis Endometrium Female Heparin-binding EGF-like Growth Factor Heparin-binding EGF-like Growth Factor Heparin-binding EGF-like Growth Factor Heparin-binding EGF-like Growth Factor Humans Infertility, Female Infertility, Female Infertility, Female Integrin beta3 Integrin beta3

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