Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis

Kevin G Osteen, Osteen KG, Kaylon L Bruner-Tran, Kaylon L. Bruner‐Tran, Eisenberg E, Esther Eisenberg
Fertility and Sterility · 2005 · vol. 83(3) , pp. 529–537 · doi:10.1016/j.fertnstert.2004.11.026 · PMID:15749474 · W1966049599
review OA: bronze CC0 ⤵ 94 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper investigates how reduced progesterone signaling during the menstrual cycle's luteal phase may increase the risk of developing endometriosis.

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Abstract

ObjectiveTo discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis.DesignA review of experimental evidence regarding the failure of P to regulate the expression of matrix metalloproteinases (MMPs) in the endometrium of patients with endometriosis.Conclusion(s)Progesterone and locally produced differentiation factors act cooperatively to reduce MMP expression by maternal endometrial cells within the pro-inflammatory micro-environment of early pregnancy. Our in vitro studies with normal human endometrium demonstrate that prior P exposure not only down-regulates MMP expression, but also limits the ability of locally produced proinflammatory cytokines to stimulate expression of these enzymes. In contrast, endometrial tissues from women with endometriosis demonstrate an altered response to P, allowing a continuous expression of MMPs throughout the secretory phase. Although the factors that influence the loss of P sensitivity in the endometrium of patients with endometriosis have not yet been defined, alterations in cell-cell communication seem to contribute to dysregulated MMP expression. Specifically, proinflammatory cytokines produced by epithelial cells oppose stromal cell responses to P, inhibiting production of key differentiation factors necessary for cell-specific MMP regulation. The resulting loss in normal MMP regulation enhances the invasive capacity of endometrial tissue, promoting ectopic establishment in an experimental model.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Progesterone Endometriosis Endometrium Female Humans Pregnancy Progesterone Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (70)

Cited by (50)

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License: CC0 · commercial use OK