Progesterone Receptor B (PGR-B) Is Partially Methylated in Eutopic Endometrium From Infertile Women With Endometriosis

Carlos Valério da Rocha Júnior, Carlos Valério Rocha-Junior, Carlos Valério Rocha, Michele Gomes Da Broi, Cristiana Libardi Miranda-Furtado, Cristiana Libardi Miranda Furtado, Paula Andrea Navarro, Rui Alberto Ferriani, Juliana Meola
Reproductive sciences (Thousand Oaks, Calif.) · 2019 · vol. 26(12) , pp. 1568–1574 · doi:10.1177/1933719119828078 · PMID:30782101 · W2918152109
article OA: closed CC0 ⤵ 38 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

PGR-B showed increased partial methylation in endometrium from infertile women with endometriosis compared to controls, while PGR-A remained unmethylated.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This case–control study investigated DNA methylation of progesterone receptor isoform–specific promoter regions for PGR-A and PGR-B in eutopic endometrium from infertile women with endometriosis versus infertile controls, sampled during the secretory phase and dated by Noyes’ criteria. DNA methylation percentages at the PGR-A and PGR-B regions were measured using high-resolution melting assay in endometrial biopsies from 19 patients (10 with endometriosis; 9 controls). PGR-A showed 0% methylation in both groups, whereas PGR-B was partially methylated in most endometriosis patients (about 50% methylation in 7 patients) compared with lower methylation in controls (about 20%; P = .04). This paper reports methylation differences without directly measuring PGR-B gene expression as a limitation. This paper is centrally about endometriosis — it links partial PGR-B promoter methylation in eutopic endometrium to infertility-associated progesterone receptor dysregulation in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Infertility, Female Receptors, Progesterone Case-Control Studies DNA Methylation Endometriosis Endometriosis Endometrium Female Humans Infertility, Female Infertility, Female Prospective Studies Receptors, Progesterone Receptors, Progesterone

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