PREDICTORS OF DRUG RESISTANCE DEVELOPMENT IN HORMONE THERAPY FOR ENDOMETRIOSIS

Трубникова Лариса Игнатьевна, Антонеева Инна Ивановна, Marina Aleksandrovna Iglina, Alina Vyacheslavovna Klykova, Ekaterina Aleksandrovna Dimitrienko
In: Ulyanovsk Medico-biological Journal · 2026 · pp. 18–30 · doi:10.34014/2227-1848-2026-1-18-30 · W7154603055
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review identified genetic polymorphisms, progesterone receptor abnormalities, microRNA dysregulation, deeply infiltrative endometriosis, and endometrial thickening as predictors of hormonal therapy resistance.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This paper studies potential predictors of resistance development to hormonal therapy in patients with endometriosis by reviewing peer-reviewed articles indexed in PubMed, GoogleScholar, CyberLeninka, and RSCI from 2015 to 2023, using keywords including endometriosis, hormonal therapy, drug resistance, and resistance predictors. The authors identify multiple candidate predictors, including genetic polymorphisms in drug-metabolizing enzymes (CYP, NAT2) and the sex hormone receptor PROGINS, abnormalities in progesterone receptor expression in endometrium, dysregulation of specific microRNAs (miR-29c, miR-196a, miR-194-3p, miR-92a), a deeply infiltrative phenotype, and endometrial thickening during therapy. A major caveat is that the study is a literature review rather than new primary data, and it does not standardize or quantify the predictive performance of each factor across studies. This paper is centrally about endometriosis—identifying predictors of resistance to hormonal therapy.

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Abstract

Endometriosis is a common gynecological condition that significantly impacts quality of life and reproductive function in women. Endometriosis is characterized by localized estrogen hypersensitivity and progesterone resistance. Hormonal therapy remains the primary medical treatment for this condition. Its pathogenetic basis is the temporary suppression of ovarian function to induce hypoestrogenism, which leads to the regression of endometriotic lesions. However, a significant proportion of patients experience an inadequate response to hormonal treatment or develop resistance to it. The aim of the study is to analyze potential predictors of resistance to hormonal treatment in patients with endometriosis. Materials and Methods. The authors reviewed the articles published in peer-reviewed journals indexed in PubMed, GoogleScholar, CyberLeninka, and the Russian Science Citation Index (RSCI) databases. The search was carried out using such keywords as ‘endometriosis,’ ‘hormonal therapy,’ ‘drug resistance,’ and ‘resistance predictors’. The search period covered from 2015 to 2023. Results. The following potential predictors of resistance were identified: genetic polymorphisms in drug-metabolizing enzymes (CYP, NAT2) and sex hormone receptors (PROGINS), abnormalities in progesterone receptor expression in the endometrium, microRNAs dysregulation (miR-29c, miR-196a, miR-194-3p, miR-92a), a deeply infiltrative disease phenotype, and thickening of the endometrium during hormonal therapy. Conclusion. Understanding and considering the multifactorial nature of drug resistance predictors offer promising avenues for optimizing and personalizing therapeutic strategies for endometriosis management.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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