Heterogeneity of estrogen receptor α and progesterone receptor distribution in lesions of deep infiltrating endometriosis of untreated women or during exposure to various hormonal treatments

Géraldine Brichant, Brichant G, Nervo P, Patricia Nervo, Adelin Albert, Albert A, Munaut C, Carine Munaut, Jean-Michel Foidart, Foidart JM, Jean‐Michel Foidart, Michelle Nisolle, Nisolle M
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2018 · vol. 34(8) , pp. 651–655 · doi:10.1080/09513590.2018.1433160 · PMID:29383962 · W2792959067
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This study found significant heterogeneity in estrogen and progesterone receptor distribution within deep infiltrating endometriosis lesions, which may explain treatment variability and failure.

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Abstract

Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a functional heterogeneity of these lesions. To evaluate the phenotype heterogeneity of cells in DIE, we measured the expression of estrogen receptor α (ERα) and of progesterone receptor (PR) in DIE of untreated women or under various treatments. We analyzed the luminal epithelial height (LEH), immunoreactive epithelial staining (IRS) and stromal staining intensity (SSI) of ERα and PR. We observed a high variability in the same gland, among distinct glands in the same sample and among distinct patients receiving the same treatment. LEH variability was primarily due to epithelial cells heterogeneity in a gland, secondarily to the glands randomly evaluated on the same section, and tertiary to the patient category. Variability in IRS and SSI scores was primarily the consequence of their heterogeneity in the same woman and to a lesser extent to variability among patients. LEH and SSI were not modified according to treatment. IRS for PR was lower in treated patients. This heterogeneity of ERα and PR distribution could explain why endocrine treatments are unable to cure this condition.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Estrogen Receptor alpha Receptors, Progesterone Contraceptives, Oral, Combined Contraceptives, Oral, Combined Endometriosis Endometriosis Endometriosis Estrogen Receptor alpha Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Progestins Progestins Receptors, Progesterone

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