A Review of the Epigenetic Contributions to Endometriosis
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⤵ 34 in-corpus citations
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This review examines epigenetic factors like DNA methylation, microRNAs, and histone modifications that are differentially expressed in endometriosis, highlighting limitations and future diagnostic and therapeutic potential.
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Abstract
Epigenetic influences have been postulated to affect the course of endometriosis. DNA methyltransferases, estrogen and progesterone receptors, micro-RNAs, and histone deacetylators, have shown differential expression in endometriosis compared with normal endometrium. Others such as aromatase, Steroid Factor-1, COX-2, and Homeobox A10 also have epigenetic modifications in endometriosis. Limitations in this area of research include heterogeneity in study design, patient populations, and methods of analysis. Larger, controlled studies are needed. Future targeted uses of this work may include using methylomes to noninvasively diagnose endometriosis, or targeting histone-deacetylase inhibitors for treatment.
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References (15)
- Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells via openalex
- Aberrant histone modification in endometriosis via openalex
- Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis via openalex
- Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise via openalex
- Epigenetic aberration of gene expression in endometriosis via openalex
- Genetic, epigenetic and stem cell alterations in endometriosis: new insights and potential therapeutic perspectives via openalex
- Systems genetics view of endometriosis: a common complex disorder via openalex
- The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis via openalex
- The role of microRNAs in endometriosis and associated reproductive conditions via openalex
- Towards an understanding of the molecular mechanism of endometriosis: unbalancing epithelial-stromal genetic conflict via openalex
- W2164385268 via openalex
- W1976214975 via openalex
- W2033570297 via openalex
- W2061893642 via openalex
- W2099631925 via openalex
Cited by (35)
- PREDICTORS OF DRUG RESISTANCE DEVELOPMENT IN HORMONE THERAPY FOR ENDOMETRIOSIS 2026
- Circular RNAs in endometriosis analyzed through RNA sequencing and bioinformatics for expression profile 2025
- The Effect of EGFR DNA Methylation on the Incident of Endometriosis 2024
- An update on epigenetic mechanisms in endometriosis 2024
- Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis 2023
- The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis 2023
- Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics 2023
- The Role of Epigenetics in Endometriosis 2023
- Endometriosis and inflammatory immune responses: Indian experience 2022
- Endometrial Cells Acutely Exposed to Phthalates In Vitro Do Not Phenocopy Endometriosis 2022
- Aberrant epigenetic regulation of estrogen and progesterone signaling at the level of endometrial/endometriotic tissue in the pathomechanism of endometriosis 2022
- Genital endometriosis and fertility 2022
- Regulation of progesterone receptor expression in endometriosis, endometrial cancer, and breast cancer by estrogen, polymorphisms, transcription factors, epigenetic alterations, and ubiquitin-proteasome system 2022
- Protocol for a case–control study investigating the clinical phenotypes and genetic regulation of endometriosis in Indian women: the ECGRI study 2021
- Protocol for a case–control study investigating the clinical phenotypes and genetic regulation of endometriosis in Indian women: the ECGRI study 2021
- Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis 2021
- Effect of Protoberberine-Rich Fraction of Chelidonium majus L. on Endometriosis Regression 2021
- Modern view on the etiology-pathogenesis and risk factors of endometriosis 2021
- Hormonal Treatment of Bowel Endometriosis 2020
- Postmenopausal endometriosis 2020
- Pathogenomics of Endometriosis Development 2020
- Shared Molecular Features Linking Endometriosis and Obstetric Complications 2020
- The epidemiology of endometriosis is poorly known as the pathophysiology and diagnosis are unclear 2020
- Endometriosis: What is the Influence of Immune Cells? 2020
- Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis 2020
- Hormones and Inflammation: An Update on Endometriosis 2019
- Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation 2019
- Prognostic importance of atypical endometriosis with architectural hyperplasia versus cytologic atypia in endometriosis-associated ovarian cancer 2019
- Dioxin and endometriosis: a new possible relation based on epigenetic theory 2019
- Endometriosis-associated ovarian cancer: What have we learned so far? 2019
- Epidemiological aspects of the outcomes from the treatment of endometriosis: Experience from two different geographical areas 2019
- Progesterone Resistance and Adult Stem Cells’ Genomic and Epigenetic Changes in the Puzzle of Endometriosis 2019
- Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis 2018
- Pathogenomics of Endometriosis Development 2018
- Endometriosis 2017
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- europepmc
- last seen: 2026-09-21T06:08:07.822426+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:20:19.560968+00:00
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