Postmenopausal endometriosis

V. E. Balan, E. I. Yermakova, Е.В. Тихомирова, A. V. Tsar'kova
In: Rossiiskii vestnik akushera-ginekologa · 2020 · vol. 20(1) , pp. 39 · doi:10.17116/rosakush20202001139 · W3009424275
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review summarizes current literature on postmenopausal endometriosis, covering epidemiology, pathogenesis, treatment principles, and the risk of malignancy and recurrence with menopausal hormone therapy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper reviews postmenopausal endometriosis as an estrogen-dependent condition that is often presumed to “fade” with menopause, but for which clinical recurrences, de novo cases, and increasing evidence of persistence are reported. Using narrative synthesis of historical case reports, retrospective epidemiology, and mechanistic hypotheses, it estimates that prevalence in peri- and postmenopausal women is around 2–5% (with examples from surgical series, including a German analysis of 42,079 cases), and discusses uncertainty about whether postmenopausal disease represents continuation versus new onset, with proposed roles for extra-glandular estrogen synthesis and an estrogen “threshold/persistent loop” in ectopic tissue. Limitations are that the paper is not a single original study and relies on heterogeneous evidence, and it notes that pathophysiology remains incompletely understood. It also relates to endometriosis management by summarizing randomized trial data and guideline recommendations on menopausal hormone therapy and by describing case reports linking tamoxifen to endometriosis and endometrial carcinoma, while discussing how endometriotic lesions remain biologically active in low-estrogen postmenopausal conditions. This paper is centrally about endometriosis — specifically, it focuses on postmenopausal endometriosis, its epidemiology, pathogenesis, and hormonal associations.

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Abstract

Представлен обзор современных источников литературы, посвященный вопросам эпидемиологии, патогенеза эндометриоза в постменопаузе, а также принципам ведения пациенток с данным заболеванием. В статье изложены результаты опубликованных работ по вопросам истории, распространенности, этиопатогенеза постменопаузального эндометриоза и методов лечения таких пациенток. Кроме того, рассмотрены вопросы малигнизации эндометриоидных очагов и влияния менопаузальной гормональной терапии на риск развития рецидивов заболевания.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (40)

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last seen: 2026-06-10T17:14:06.276822+00:00
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