Dioxin and endometriosis: a new possible relation based on epigenetic theory

Pierluigi Giampaolino, Luigi Della Corte, Virginia Foreste, Fabio Barra, Simone Ferrero, Giuseppe Bifulco
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · vol. 36(4) , pp. 279–284 · doi:10.1080/09513590.2019.1698024 · PMID:31805795 · W2994008303
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This review explores the potential role of dioxin-induced epigenetic modifications in the development of endometriosis, a chronic gynecological condition.

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Abstract

Endometriosis is a chronic disease characterized by the growth of endometrial-like glands and stroma outside the uterine cavity. Nowadays, the exact etiology of endometriosis is unclear and the interaction between a variety of environmental physical and chemical compounds may potentially promote the disease in women with an individual susceptibility. The first demonstration of a relation between an environmental factor and endometriosis was obtained with the chronic dietary exposure of a primate colony to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Besides the well-known dioxin's pathway of action, several papers are focusing on the role of epigenetic mechanisms, a way through which the genome responds to the environment and can lead to permanent changes in gene expression until affecting the phenotypes or cause disease. In this review, we focus on the possible role of dioxin epigenetics modification in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Dioxins Endometriosis Endometriosis Epigenesis, Genetic Animals Dioxins Endometriosis Endometriosis Endometrium Endometrium Endometrium Epigenesis, Genetic Epigenesis, Genetic Female Gene-Environment Interaction Genetic Predisposition to Disease Humans Intestinal Diseases Intestinal Diseases Intestinal Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (68)

Cited by (20)

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