The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cells

Wu Y, Yan Wu, Xuerong Shi, Shi X, Sun‐Wei Guo, Sun-Wei Guo, Guo SW
Fertility and sterility · 2008 · vol. 90(4) , pp. 1320–1323 · doi:10.1016/j.fertnstert.2007.10.049 · PMID:18249378 · W2032505339
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This study investigated the role of progesterone receptor isoform B (PR-B) in immortalized endometrial stromal cells and found that its knockdown promotes cell proliferation.

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Abstract

The knockdown of PR-B by siRNA resulted in a significant increase in proliferation in an immortalized endometrial stromal cell line. This suggests that PR-B knockdown might be responsible, at least in part, for increased proliferation and resistance to apoptosis as seen in the eutopic and ectopic endometrium of women with endometriosis.

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MeSH descriptors

Endometrium Endometrium Receptors, Progesterone Cell Line Cell Proliferation Endometrium Female Gene Silencing Gene Silencing Humans Receptors, Progesterone Receptors, Progesterone Stromal Cells Stromal Cells Stromal Cells

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