Epigenetic background of the most common non-oncologic gynecological diseases

József Gábor Joó, Éva Csatlós, Réka Brubel, Attila Bokor, Csaba Karabélyos, János Rigó
In: Orvosi Hetilap · 2014 · vol. 155(13) , pp. 492–499 · doi:10.1556/oh.2014.29860 · W2200718990
review OA: bronze CC0
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses the epigenetic mechanisms potentially involved in the etiology of uterine fibroids, endometriosis, and polycystic ovary syndrome, highlighting their role as future therapeutic targets.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This narrative review discusses how epigenetic mechanisms, particularly chromatin-related processes such as DNA methylation, histone modifications, and non-coding RNAs, regulate gene activity under environmental influences. It links aberrant epigenetic regulation to the etiologies of several common non-oncologic gynecological conditions, highlighting that uterine fibroids likely involve complex epigenetic control, endometriosis has a multifactorial origin with immunological and hormonal contributors that are influenced by epigenetics, and polycystic ovary syndrome may have an in utero origin shaping research directions. The paper explicitly describes a caveat in that most of its content is mechanistic and integrative rather than based on a single original experimental study. This paper is centrally about endometriosis — it summarizes the multifactorial origins of endometriosis and frames immunological and hormonal mechanisms as being influenced by epigenetic factors.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Epigenetic effects influence the function of genes regulating the main physiological mechanisms. Some of these environmental factors may reduce or inhibit the function of these genes. The environmental effects on gene function may result in a change of the DNA structure leading to non-heritable phenotype changes. Epigenetic factors play an important etiological role in the development of numerous diseases in obstetrics and gynecology. Uterine fibroids probably have a complex etiological background including epigenetic mechanisms. The multifactorial aetiology of endometriosis suggests key roles for immunological and hormonal factors in the development of the diseases. These mechanisms are influenced by epigenetic factors, which may serve as therapeutic targets in the future. The possible in utero origin of polycystic ovary syndrome determines the main directions of research concerning epigenetic factors in the etiological background, with the hope of eventual prevention and/or treatment in the preconceptional period as well as during pregnancy care. Orv. Hetil., 2014, 155(13), 492–499.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (52)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK