Prolonged stimulation with tumor necrosis factor-α induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells
article
OA: closed
CC0
⤵ 50 in-corpus citations
AI-generated summary
Tumor necrosis factor-α prolonged stimulation induced partial methylation at the PR-B promoter in immortalized epithelial-like endometriotic cells.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
The promoter of P receptor isoform B (PR-B) has recently been shown to be hypermethylated in endometriotic tissues, but one question remains as what causes the aberrant methylation. We show that sustained stimulation of an epithelial-like endometriotic cell line with tumor necrosis factor alpha stimulation for 30 days induced partial methylation in the promoter region of PR-B with concomitant reduction of PR-B expression.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (30)
- Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis via openalex
- Identification of an Invasive, N-Cadherin-Expressing Epithelial Cell Type in Endometriosis Using a New Cell Culture Model via openalex
- Immunobiology of endometriosis via openalex
- Inhibition of Proliferation of Endometrial Stromal Cells by Trichostatin A, RU486, CDB-2914, N-Acetylcysteine, and ICI 182780 via openalex
- Is Endometriosis Associated with Systemic Subclinical Inflammation? via openalex
- Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? via openalex
- Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Endometriosis via openalex
- Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis via openalex
- Role of cytokines in endometriosis via openalex
- The Estrogen Early Response Gene FOS Is Altered in a Baboon Model of Endometriosis1 via openalex
- The Role of Cytokines in Endometriosis* via openalex
- W2122066579 via openalex
- W2122994808 via openalex
- W2143762235 via openalex
- W2162764250 via openalex
- W2324384090 via openalex
- W4211081176 via openalex
- W6678029821 via openalex
- W6678483006 via openalex
- W6681302908 via openalex
- W1994465394 via openalex
- W2001963326 via openalex
- W2013050589 via openalex
- W2030069314 via openalex
- W2031089158 via openalex
- W2040257851 via openalex
- W2059479474 via openalex
- W2065643273 via openalex
- W2109801386 via openalex
- W2121585544 via openalex
Cited by (50)
- Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways 2026
- Results of dienogest treatment and its discontinuation in patients with symptomatic adenomyosis: a prospective cohort study 2025
- Epigenetics of endometriosis 2025
- Immunologic Aspects of Endometriosis 2024
- Progesterone Resistance in Endometriosis: Current Evidence and Putative Mechanisms 2023
- Non-response to first-line hormonal treatment for symptomatic endometriosis: overcoming tunnel vision. A narrative review 2023
- From Retrograde Menstruation to Endometrial Determinism and a Brave New World of "Root Treatment" of Endometriosis: Destiny or a Fanciful Utopia? 2023
- Distinct subtypes of endometriosis identified based on stromal-immune microenvironment and gene expression: implications for hormone therapy 2023
- Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis 2023
- Progesterone receptor ligands for the treatment of endometriosis 2022
- Progesterone Actions and Resistance in Gynecological Disorders 2022
- Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology 2022
- Epithelial-to-mesenchymal transition contributes to the downregulation of progesterone receptor expression in endometriosis lesions 2021
- Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure 2020
- Epigenetics of Estrogen and Progesterone Receptors in Endometriosis 2020
- Impaired pathogen-induced autophagy and increased IL-1β and TNFα release in response to pathogenic triggers in secretory phase endometrial stromal cells of endometriosis patients 2020
- Three-Dimensional Biofabrication Models of Endometriosis and the Endometriotic Microenvironment 2020
- Three-Dimensional Biofabrication Models of Endometriosis and the Endometriotic Microenvironment 2020
- Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology 2019
- Endometriosis and nuclear receptors 2019
- Endometriosis and Epigenetics: What do we Know? 2018
- Progesterone Resistance in Endometriosis: an Acquired Property? 2018
- Epigenetics of Endometriosis 2018
- Progesterone resistance in endometriosis: origins, consequences and interventions 2017
- Epigenetic regulation of the pathological process in endometriosis 2017
- Progesterone Alleviates Endometriosis via Inhibition of Uterine Cell Proliferation, Inflammation and Angiogenesis in an Immunocompetent Mouse Model 2016
- Innovations in classical hormonal targets for endometriosis 2015
- Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells 2015
- Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility 2015
- Endometriosis and possible inflammation markers 2015
- Epigenetics in Endometriosis 2014
- Influence of AKT on Progesterone Action in Endometrial Diseases 2014
- Potential New Drugs for Endometriosis: Experimental Evidence 2014
- Epigenetic background of the most common non-oncologic gynecological diseases 2014
- Decreased expression of mucin-1 in endometriosis endometrium correlated with progesterone receptor B involved in infertility 2014
- Epigenetic aberration of gene expression in endometriosis 2013
- Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. 2013
- Western Herbal Medicine, Epigenetics, and Endometriosis 2013
- Valproic Acid and Progestin Inhibit Lesion Growth and Reduce Hyperalgesia in Experimentally Induced Endometriosis in Rats 2012
- The Epigenetics of Endometriosis 2012
- Genetic Polymorphisms of DNMT3L Involved in Hypermethylation of Chromosomal Ends Are Associated with Greater Risk of Developing Ovarian Endometriosis 2012
- Aberrant DNA methylation status of endometriosis: Epigenetics as the pathogenesis, biomarker and therapeutic target 2011
- Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target 2011
- Research Resource: Genome-Wide Profiling of Methylated Promoters in Endometriosis Reveals a Subtelomeric Location of Hypermethylation 2010
- Constitutive and Tumor Necrosis Factor-Alpha-Stimulated Activation of Nuclear Factor-KappaB in Immortalized Endometriotic Cells and Their Suppression by Trichostatin A 2010
- Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms 2009
- Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms 2009
- Emerging drugs for endometriosis 2008
- Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans 2008
- The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cells 2008
Source provenance
- europepmc
- last seen: 2026-08-16T09:21:09.727480+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:14:48.452140+00:00
License: CC0
· commercial use OK