Influence of AKT on Progesterone Action in Endometrial Diseases

Irene I Lee, Irene Lee, J Julie Kim, Julie Kim
Biology of reproduction · 2014 · vol. 91(3) , pp. 63 · doi:10.1095/biolreprod.114.119255 · PMID:25100707 · PMC4435059 · W2069554427
review OA: bronze CC0 ⤵ 15 in-corpus citations
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This review summarizes recent studies on how AKT signaling pathway activation impacts progesterone receptor function in endometrial diseases like endometriosis and endometrial cancer.

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Abstract

Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signaling pathway is often overactive in endometrial pathologies and promotes the survival and proliferation of the diseased cells. Understanding how AKT influences progesterone action is critical in improving hormone-based therapies in endometrial pathologies. Here, we summarize recent studies investigating the crosstalk between the AKT pathway and progesterone receptor function in endometriosis and endometrial cancer.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Progesterone Progestins Proto-Oncogene Proteins c-akt Receptors, Progesterone Signal Transduction Uterine Diseases Animals Cell Proliferation Cell Proliferation Endometrium Endometrium Endometrium Female Humans Progesterone Progestins Proto-Oncogene Proteins c-akt Receptors, Progesterone Receptors, Progesterone

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (15)

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europepmc
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License: CC0 · commercial use OK