Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility

Annunziata M, Marta Annunziata, Raúl M. Luque, Raul M Luque, Mario Durán-Prado, Mario Durán‐Prado, Alessandra Baragli, Baragli A, Grande C, Cristina Grande, Volante M, Marco Volante, Manuel D. Gahete, Francesco Deltetto, Deltetto F, Marco Camanni, Camanni M, Ghigo E, Ezio Ghigo, Justo P. Castaño, Riccarda Granata
Human Reproduction · 2012 · vol. 27(7) , pp. 2117–2129 · doi:10.1093/humrep/des144 · PMID:22588000 · W2151646340
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Somatostatin, its analogues, and cortistatin reduced PDGF-induced proliferation and motility in human endometriotic stromal cells by downregulating ERK1/2 phosphorylation.

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Abstract

BACKGROUND: Endometriosis is characterized by ectopic implantation of endometrial cells, which show increased proliferation and migration. Somatostatin (SST) and its analogues inhibit normal and cancer cell growth and motility through the SST receptors, sst1-5. Cortistatin (CST), which displays high structural and functional homology with SST, binds all ssts, as well as MrgX2. Our objective was to investigate the gene expression of the SST/CST system and to determine the effect of SST and its analogues on platelet-derived growth factor (PDGF)-induced proliferation and motility in telomerase-immortalized human endometrial stromal cell (T HESC) line and in primary endometrial stromal cell (ESCs) isolated from human endometriotic tissues. METHODS: Ectopic endometrial tissues were collected from women (n= 23) undergoing laparoscopic surgery for endometriosis (Stage III/IV). Gene expression was evaluated by real-time PCR, cell motility by wound healing assay, protein expression and β-actin rearrangement by immunofluorescence, cell proliferation by the Alamar blue assay and ERK1/2 and Akt phosphorylation by western blot. RESULTS: Human endometriotic tissues, primary ESCs and T HESCs expressed SST, CST and ssts. SST, its analogues SOM230 and octreotide, as well as CST, counteracted PDGF-induced proliferation and migration in both ESCs and T HESCs. SST also inhibited vascular endothelial growth factor and metalloprotease-2 mRNA expression, and reduced basal and PDGF-induced ERK1/2 phosphorylation. CONCLUSION: These results indicate that the SST/CST system is expressed in endometriotic tissues and cells. The inhibitory effects of SST and its analogues on PDGF-induced proliferation and motility suggest that these peptides may represent promising tools in the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Gene Expression Regulation Platelet-Derived Growth Factor Somatostatin Somatostatin Cell Movement Cell Proliferation Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Models, Biological Nerve Tissue Proteins Nerve Tissue Proteins Neuropeptides Neuropeptides Phosphorylation Platelet-Derived Growth Factor

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