Expression of somatostatin and its receptor�1‑5 in endometriotic tissues and cells

Yanhua Zhao, Lin Peng, Xiang Li, Yi Zhang
Experimental and therapeutic medicine · 2018 · vol. 16(5) , pp. 3777–3784 · doi:10.3892/etm.2018.6730 · PMID:30405748 · PMC6201141 · W2892226790
article OA: gold CC0 ⤵ 2 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Somatostatin is highly expressed in endometriotic cells, and somatostatin receptors 1-5 are present in endometriotic and eutopic tissues, with expression levels associated with disease stage.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study examined somatostatin (SS) and somatostatin receptor (SSTR1–5) expression in endometriosis by analyzing ectopic endometrial cells and tissues from 30 patients, along with eutopic endometrium from additional patients and normal endometrium from controls using RT-qPCR for SS and immunohistochemistry for SSTR1–5. SS mRNA was significantly higher in ectopic endometrial cells, while SSTR1–5 were detected in ectopic and eutopic endometrium with positive rates that differed by receptor subtype and were higher overall in ectopic and eutopic tissue than in normal endometrium; importantly, expression across SSTR subtypes in ectopic tissue was associated with Revised American Fertility Society staging. The authors did not report an in vivo functional effect of SS/SSTR signaling, and the work was limited to expression measurements without mechanistic experiments. This paper is centrally about endometriosis — it characterizes SS and SSTR1–5 expression patterns in ectopic, eutopic, and normal endometrial tissues and links them to disease stage.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

The present study aimed to detect the expression of somatostatin (SS) and SS receptor (SSTR)1-5 in tissues from patients with endometriosis (EMS). Reverse transcription-quantitative polymerase chain reaction analysis was applied to examine the expression of somatostatin gene in ectopic endometrial cells (EECs). The expression of somatostatin receptor 1-5 in the ectopic endometrium (EE), eutopic endometrium and normal endometrium and their association with EMS staging were determined by immunohistochemistry. The results indicated that the expression of SS in EECs was significantly higher compared with that in the control group. SSTR1-5 were expressed in the EE tissues from 30 patients with EMS, and the positive rates were 43.3, 70.0, 53.3, 50.0 and 96.7%, respectively, which were closely associated with EMS staging of the patients. The positive rates of SSTR1-5 expression in the eutopic endometrium from 12 patients with EMS were 33.3, 41.7, 58.3, 58.3 and 83.3%, respectively, while the positive rates of SSTR1-5 expression in the normal endometrium from 14 women without EMS were 7.1, 7.1, 21.4, 28.6 and 64.3%, which were lower than the positive rates of SSTR1-5 in the EE (43.3, 70, 53.3, 50 and 96.7%) and eutopic endometrial cells (33.3, 41.7, 58.3, 58.3 and 83.3%). In conclusion, SS was highly expressed in EECs. SSTR1-5 were expressed in the ectopic as well as eutopic endometrium, and low or moderate expression of SSTR1-4 and high expression of SSTR5 were detected in the ectopic and eutopic endometrial tissues, while low expression of SSTR1-4 and partial expression of SSTR5 were detected in normal endometrium. The positive rates of expression of SSTR1-5 in the EE cells and eutopic endometrium were higher than those in the normal endometrium. The expression of all the subtypes of SSTR in the EE tissues was closely associated with EMS staging.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (51)

Cited by (2)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:19:25.021412+00:00
License: CC0 · commercial use OK