Immunoscintigraphy of endometriosis

Stephen Kennedy, S H Kennedy, Kennedy SH, O. A. Mojiminiyi, Olusegun A. Mojiminiyi, Mojiminiyi OA, Nigel Soper, N D Soper, Soper ND, Shepstone BJ, B. J. Shepstone, D H Barlow, David H. Barlow, Barlow DH
British journal of obstetrics and gynaecology · 1990 · vol. 97(8) , pp. 667–670 · doi:10.1111/j.1471-0528.1990.tb16235.x · PMID:2400745 · W1983069334
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Immunoscintigraphy using radiolabeled OC-125 F(ab')2 fragments demonstrated 89% sensitivity and 33% specificity for diagnosing endometriosis in women with suspected pelvic disease.

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Abstract

Twenty-eight women with suspected endometriosis or infertility, or both, received radiolabelled monoclonal antibody OC-125 F(ab')2 fragments before surgery in a study to determine whether foci of pelvic endometriosis could be displayed with immunoscintigraphy. Immunoscintigraphy was positive in 22 women (16 with endometriosis, two with pelvic adhesions, one with pelvic inflammatory disease and one with normal pelvic findings) and negative in five women (two with endometriosis and three with normal pelvic findings). One woman developed a hypersensitivity reaction and, therefore, did not receive the radiolabelled fragments. The method had 89% sensitivity and 33% specificity for the diagnosis of endometriosis; it had 91% sensitivity and 60% specificity for the diagnosis of benign pelvic disease.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Immunoglobulin Fab Fragments Ovarian Neoplasms Adult Adult Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Humans Humans Immunoglobulin Fab Fragments Immunoglobulin Fab Fragments

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

Cited by (6)

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