Genome-wide profiling of miRNA expression patterns in tubal endometriosis

Hang Qi, Qi H, Liang G, Guiling Liang, Yu J, Jin Yu, Xiaofeng Wang, Wang X, Yan Liang, Liang Y, He X, Xiaoqing He, Feng T, Tienan Feng, Jian Zhang, Zhang J
Reproduction (Cambridge, England) · 2019 · vol. 157(6) , pp. 525–534 · doi:10.1530/rep-18-0631 · PMID:30909166 · W2936420571
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This study identified 17 differentially expressed miRNAs and 4343 target genes in tubal endometriosis, revealing that the mTOR signaling pathway and vesicular transport are key in its pathogenesis.

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Abstract

MicroRNA (miRNA) expression profiles in tubal endometriosis (EM) are still poorly understood. In this study, we analyzed the differential expression of miRNAs and the related gene networks and signaling pathways in tubal EM. Four tubal epithelium samples from tubal EM patients and five normal tubal epithelium samples from uterine leiomyoma patients were collected for miRNA microarray. Bioinformatics analyses, including Ingenuity Pathway Analysis (IPA), Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, were performed. Quantitative real-time polymerase chain reaction (qRT-PCR) validation of five miRNAs was performed in six tubal epithelium samples from tubal EM and six from control. A total of 17 significantly differentially expressed miRNAs and 4343 potential miRNA-target genes involved in tubal EM were identified (fold change >1.5 and FDR-adjusted P value <0.05). IPA indicated connections between miRNAs, target genes and other gynecological diseases like endometrial carcinoma. GO and KEGG analysis revealed that most of the identified genes were involved in the mTOR signaling pathway, SNARE interactions in vesicular transport and endocytosis. We constructed an miRNA-gene-disease network using target gene prediction. Functional analysis showed that the mTOR pathway was connected closely to tubal EM. Our results demonstrate for the first time the differentially expressed miRNAs and the related signal pathways involved in the pathogenesis of tubal EM which contribute to elucidating the pathogenic mechanism of tubal EM-related infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fallopian Tubes Gene Expression Profiling Gene Regulatory Networks Genome, Human MicroRNAs Adult Case-Control Studies Computational Biology Endometriosis Endometriosis Fallopian Tubes Fallopian Tubes Female Humans MicroRNAs Middle Aged Signal Transduction

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