Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions

Bin Wang, Mingxia Gao, Ying Yao, Hongwei Li, Xuehong Zhang
Molecular biology reports · 2024 · vol. 51(1) , pp. 359 · doi:10.1007/s11033-023-08937-w · PMID:38400863 · W4392128906
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This review summarizes research on the mTOR signaling pathway's role in endometrial physiology and pathology, including its influence on receptivity, decidualization, endometriosis, and endometrial cancer.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This review discusses the mammalian target of rapamycin (mTOR) serine/threonine kinase and its signaling roles in endometrial physiology and pathology, synthesizing recent research on how mTOR influences endometrial cell differentiation, proliferation, receptivity, decidualization, and autophagy. The paper reports that mTOR activity supports growth and maturation of endometrial cells and can also contribute to the development of endometriosis and endometrial cancer, highlighting mTOR pathway components as potential therapeutic targets while summarizing mechanistic findings across the field. A major caveat is that, as a narrative review, it does not provide new experimental data and does not standardize evidence quality or quantify effect sizes across included studies. This paper is centrally about endometriosis and related uterine pathology — focusing on mTOR signaling in the endometrium and how it contributes to the development of endometriosis.

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Abstract

The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase crucial for cellular differentiation, proliferation, and autophagy. It shows a complex role in the endometrium, influencing both normal and pathogenic conditions. mTOR promotes the growth and maturation of endometrial cells, enhancing endometrial receptivity and decidualization. However, it also contributes to the development of endometriosis (EMs) and endometrial cancer (EC), thus emerging as a therapeutic target for these conditions. In this review, we summarize recent research progress on the mTOR signalling pathway in the endometrium. This provides insights into female endometrial structure and function and guides the prevention and treatment of related diseases.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (2)

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License: CC0 · commercial use OK