Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions

The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase crucial for cellular differentiation, proliferation, and autophagy. It shows a complex role in the endometrium, influencing both normal and pathogenic conditions. mTOR promotes the growth and maturation of endometrial cells, enhancing endometrial receptivity and decidualization. However, it also contributes to the development of endometriosis (EMs) and endometrial cancer (EC), thus emerging as a therapeutic target for these conditions. In this review, we summarize recent research progress on the mTOR signalling pathway in the endometrium. This provides insights into female endometrial structure and function and guides the prevention and treatment of related diseases. Similar content being viewed by others Data and material availability The data and material that support this review are openly available.

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None. Funding This work was supported by the Hospital Fund Projects of the First Hospital of Lanzhou University [ldyyyn2018-05] and the Natural Science Foundation of Gansu Province [18JR3RA304]. Author information Authors and Affiliations Contributions BW, YY and HL wrote the manuscript. XZ and MG designed and revised the manuscript. All authors have approved this version of the article. Corresponding author Ethics declarations Conflict of interest The authors report no conflict of interest. Ethical approval This review does not contain any studies with human participants or animals performed by the authors. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Wang, B., Gao, M., Yao, Y. et al. Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions. Mol Biol Rep 51, 359 (2024). https://doi.org/10.1007/s11033-023-08937-w Received: Accepted: Published: Version of record: DOI: https://doi.org/10.1007/s11033-023-08937-w