{"paper_id":"04843d36-4e14-419e-86e0-dfbc108c2d55","body_text":"Abstract\nThe mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase crucial for cellular differentiation, proliferation, and autophagy. It shows a complex role in the endometrium, influencing both normal and pathogenic conditions. mTOR promotes the growth and maturation of endometrial cells, enhancing endometrial receptivity and decidualization. However, it also contributes to the development of endometriosis (EMs) and endometrial cancer (EC), thus emerging as a therapeutic target for these conditions. In this review, we summarize recent research progress on the mTOR signalling pathway in the endometrium. 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All authors have approved this version of the article.\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors report no conflict of interest.\nEthical approval\nThis review does not contain any studies with human participants or animals performed by the authors.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nWang, B., Gao, M., Yao, Y. et al. Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions. Mol Biol Rep 51, 359 (2024). https://doi.org/10.1007/s11033-023-08937-w\nReceived:\nAccepted:\nPublished:\nVersion of record:\nDOI: https://doi.org/10.1007/s11033-023-08937-w","source_license":"CC0","license_restricted":false}