Effects of pelvic endometriosis and adenomyosis on ciliary beat frequency and muscular contractions in the human fallopian tube

Wei Xia, Duo Zhang, Jing Ouyang, Yan Liang, Huiyu Zhang, Zhen Huang, Guiling Liang, Qian Zhu, Xiaoming Guan, Jian Zhang
Reproductive biology and endocrinology : RB&E · 2018 · vol. 16(1) , pp. 48 · doi:10.1186/s12958-018-0361-y · PMID:29753325 · PMC5948789 · W2806136513
article OA: gold CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Endometriosis significantly reduced human fallopian tube ciliary beat frequency, ciliated cell percentage, and muscular contractility, especially with tubal involvement, while adenomyosis did not alter these functions.

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Abstract

BACKGROUND: Pelvic endometriosis (EM) and adenomyosis (AM) have different effects on the fallopian tube. This study aimed to assess the transport capability of the fallopian tube in women with pelvic EM or AM. METHODS: Twenty women with uterine leiomyoma (control group), 20 with adenomyosis without pelvic EM (AM group) and 35 with pelvic EM without AM (EM group) were included. EM cases were further divided into the tubal EM and non-tubal EM subgroups. Ciliary beat frequency (CBF), percentage of ciliated cells, and smooth muscle contraction were measured. RESULTS: CBFs of the ampulla in EM cases were significantly lower than those of control and AM cases; CBFs of the ampulla and isthmus in tubal EM cases were significantly lower than those of the control group and non-tubal EM subgroup. In both the ampulla and isthmus segment, percentages of ciliated cells in EM patients were significantly lower than those of AM and control patients; the tubal EM subgroup showed significantly lower values than the control group and non-tubal EM subgroup. Amplitude-to-weight ratios of longitudinal muscular contractility in EM cases were significantly lower than control values; tubal EM cases showed significantly lower values than controls and the non-tubal EM subgroup. Contraction frequencies in EM cases were significantly lower than those of control and AM cases, in both longitudinal and circular muscles; tubal EM cases showed significantly lower values than controls and the non-tubal EM subgroup. CONCLUSION: EM with tubal EM damaged transport function of the fallopian tube, to varying degrees, whereas tubal function in EM without tubal EM and in AM is not altered.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Cilia Endometriosis Fallopian Tubes Muscle Contraction Pelvic Floor Disorders Adenomyosis Adenomyosis Adult Case-Control Studies Cilia Endometriosis Endometriosis Fallopian Tubes Fallopian Tubes Female Humans Middle Aged Muscle Contraction Organ Culture Techniques

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (16)

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