Peritoneal fluid, endometriosis, and ciliary beat frequency in the human fallopian tube

R.A. Lyons, Lyons RA, Rachel A Lyons, Ovrang Djahanbakhch, Djahanbakhch O, O. Djahanbakhch, Ertan Saridogan, Ertan Sarıdoğan, Saridogan E, Alan A Naftalin, A. A. Naftalin, Naftalin AA, Mahmood T, Tariq Mahmood, A. R. L. Weekes, Anthony Weekes, Weekes A, Rashna Chenoy, Chenoy R
Lancet (London, England) · 2002 · vol. 360(9341) , pp. 1221–1222 · doi:10.1016/s0140-6736(02)11247-5 · PMID:12401250 · W2097611363
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This study investigated the relationship between peritoneal fluid composition, the presence of endometriosis, and ciliary beat frequency in the human fallopian tube.

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Abstract

Endometriosis and infertility are known to be associated, but it is unclear whether endometriosis causes infertility. We used contrast analogue enhancement to study the effect of peritoneal fluid from women with early stage endometriosis on the ciliary beat frequency of human fallopian tube epithelium. We obtained peritoneal fluid from six women with early stage endometriosis and from six fertile women with no evidence of endometriosis to use as controls. Fallopian tubes from hysterectomy specimens were collected from 17 women. The difference in ciliary beat frequency between fallopian tubes exposed to peritoneal fluids of women with and without endometriosis increased with the duration of incubation (mean difference at 24 h 1.35 Hz, 95% CI 0.94-1.75, p=0.01). At 24 h, ciliary beat frequency was significantly lower in the incubations with peritoneal fluid from women with endometriosis than controls (4.29 [0.15] vs 5.64 Hz [0.15], respectively, p=0.001). Impairment of ciliary action in women with endometriosis might reduce fertility.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Cilia Endometriosis Fallopian Tubes Infertility, Female Adult Analysis of Variance Case-Control Studies Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Middle Aged Time Factors

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Cited by (39)

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License: CC0 · commercial use OK