Reproductive biology and endocrinology : RB&E

This report explores the case of a young, normal-responder nulligravida with peritoneal endometriosis and recurrent implantation failure, with poor embryo quality during multiple failed attempts at IVF treatment. The patient underwent Dieno…

BACKGROUND: Emerging evidence suggests microbial dysbiosis may contribute to gynaecological pathologies, including endometriosis and recurrent implantation failure (RIF). The vaginal microbiome is well-characterised, with Lactobacillus-domi…

BackgroundDisturbances in the female reproductive system are known extraintestinal manifestations of celiac disease (CD). However, the reliability of the existing literature is limited by small study populations and heterogeneous study desi…

BackgroundAn increasing body of evidence indicates that exposure to metal elements may adversely affect female fertility. While the association between metal concentrations in the follicular fluid (FF) and fertility is acknowledged, the rel…

BackgroundRecombinant human luteinizing hormone (rLH) was originally introduced to supplement recombinant human follicle-stimulating hormone (rFSH) for controlled ovarian stimulation (COS) in patients with hypogonadotropic hypogonadism. Pro…

OBJECTIVE: To develop and validate a prediction model for uterine fibroid risk based on clinical characteristics and blood biochemical indicators, and to explore its risk factors and clinical application value. METHODS: This retrospective c…

The establishment of a successful pregnancy depends on proper embryo development and coordinated endometrial differentiation, particularly through the process of decidualization. Mesenchymal stem/stromal cells (MSCs), especially those deriv…

BACKGROUND: The follicular fluid (FF) microenvironment plays a critical role in oocyte maturation and embryo development, reflecting local ovarian activity and systemic metabolic status. While metabolic alterations in FF have been described…

Preimplantation genetic testing for aneuploidy (PGT-A) is widely used to screen for embryo aneuploidy, enabling the selection and transfer of genetically normal embryos. Despite its potential to improve clinical outcomes, the implementation…

BackgroundIt has recently been discovered that one of the key elements influencing endometrial receptivity is uterine peristalsis. This was a prospective cohort study aiming to assess uterine peristalsis at the time of embryo transfer in wo…

BACKGROUND: Endometriosis is a chronic inflammatory disease strongly associated with reduced oocyte quality and subfertility, yet the underlying cytoplasmic defects remain poorly understood. METHODS: Using a surgically induced autologous m…

BACKGROUND: Endometriosis is a systemic gynecological disorder affecting ~ 10% of reproductive-aged women and shares pathophysiological features with cardiovascular disease (CVD). However, its associations with cardiac remodeling and CVD ri…

BACKGROUND: Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the disease’s pathogenesis remain po…

BackgroundEndometrial intrauterine adhesions (IUA) arise due to comprised regenerative capacity of endometrium and aberrant fibrotic processes. These adhesions significantly affect fertility by impeding embryo implantation, sustaining pregn…

BackgroundEndometrial thickness (EMT) is widely monitored in assisted reproductive technology as a marker of implantation potential, yet its precise association with pregnancy and perinatal outcomes in frozen embryo transfer (FET) cycles re…

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder characterized by ectopic endometrial tissue growth, leading to chronic inflammation and pelvic pain. Despite its high prevalence, the molecular mechanisms underlying EMs rem…

OBJECTIVE: To investigate whether the clinical predictors of achieving a clinical pregnancy differ between fresh and frozen embryo transfer cycles in patients with recurrent implantation failure (RIF) undergoing their first ART treatment af…

BACKGROUND: Endometriosis is a prevalent estrogen-dependent inflammatory disorder that compromises women's quality of life and fertility through chronic pelvic pain, inflammation, and reproductive dysfunction. Current clinical management re…

BACKGROUND: The optimal interpregnancy interval (IPI) before reinitiating frozen-thawed embryo transfer (FET) after pregnancy loss remains uncertain, particularly in women undergoing assisted reproductive technology. Current guidelines reco…

BackgroundThe optimal duration of ovarian stimulation in GnRH antagonist protocols remains insufficiently explored, despite its potential impact on oocyte quality, embryo development, and endometrial receptivity. Identifying an optimal stim…

The cryopreservation of ovarian tissue can induce oxidative damage. In this study, we investigated whether low-intensity pulsed ultrasound (LIPUS) can mitigate this oxidative damage and examined the underlying molecular mechanisms. Ovarian …

BackgroundSurrogacy is considered to be a method that allows infertile couples to have a child with the assistance of a third party, known as the surrogate mother. Two forms exist: traditional surrogacy, in which the surrogate provides the …

PurposeThis study aimed to develop a predictive model for diminished ovarian reserve (DOR) in reproductive-aged women with Hashimoto's thyroiditis (HT) by integrating transvaginal three-dimensional ultrasound and clinical multimodal data, t…

INTRODUCTION: Total fertilization failure (TFF) remains a critical barrier in assisted reproductive technology (ART), occurring in 5–10% of treatment cycles. While TFF can result from both male and female gamete factors, emerging evidence s…

BACKGROUND: Literature shows that ovulation induction, intrauterine insemination, and assisted reproductive technology are independently associated with increased risks for pregnancy, perinatal, and childhood health complications. However, …