A novel approach to treating Endometriosis-Related Repeated IVF failures- insights from single case report

Raoul Orvieto
Reproductive biology and endocrinology : RB&E · 2026 · vol. 24(1) · doi:10.1186/s12958-026-01610-4 · PMID:42786469 · PMC13602600 · W7214163426
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Abstract

This report explores the case of a young, normal-responder nulligravida with peritoneal endometriosis and recurrent implantation failure, with poor embryo quality during multiple failed attempts at IVF treatment. The patient underwent Dienogest (Visabelle®) pretreatment followed by a combination protocol of Stop GnRH-agonist/GnRH-antagonist for controlled ovarian stimulation, culminating in a natural cycle frozen-thawed embryo transfer with modified luteal phase support. This combined approach produced several high-quality embryos leading to a successful singleton pregnancy. These findings provide new insights into addressing endometriosis-associated infertility and repeated IVF failure.

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MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Fertilization in Vitro Fertilization in Vitro Infertility, Female Infertility, Female Infertility, Female Nandrolone Nandrolone Nandrolone Adult Embryo Transfer Embryo Transfer Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Hormone Antagonists

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SciLite annotations

chemicals 1
dienogest

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