Decreased Progesterone Receptor B/A Ratio in Endometrial Cells by Tumor Necrosis Factor-Alpha and Peritoneal Fluid from Patients with Endometriosis

Uisoo Chae, Jin Young Min, Sung Hoon Kim, Hyo Jin Ihm, Young Sang Oh, So Yun Park, Hee Dong Chae, Chung-Hoon Kim, Chung Hoon Kim, Byung Moon Kang
Yonsei medical journal · 2016 · vol. 57(6) , pp. 1468 · doi:10.3349/ymj.2016.57.6.1468 · PMID:27593876 · PMC5011280 · W2517649574
article OA: gold CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Endometrial cells treated with TNF-α or endometriosis patient peritoneal fluid showed decreased progesterone receptor B/A ratio, and PR-B expression was lower in endometriosis tissues.

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Abstract

PURPOSE: Progesterone resistance is thought to be a major factor that contributes to progression of endometriosis. However, it is not clear what causes progesterone resistance in endometriosis. This study aimed to assess whether cytokines or peritoneal fluid can affect progesterone receptor (PR) expression in endometrial cells and to verify whether PR expression is reduced in endometriosis. MATERIALS AND METHODS: The PR-B/A ratio was measured via real-time polymerase chain reaction after in vitro culture, in which endometrial cells were treated with either tumor necrosis factor-alpha (TNF-α), interleukin-1 beta, or peritoneal fluid obtained from women with advanced-stage endometriosis. Immunohistochemistry was performed to compare PR-B expression between eutopic and ectopic endometrial tissues from women with and without advanced-stage endometriosis. RESULTS: The PR-B/A ratio was significantly decreased by treatment with either TNF-α (p=0.011) or peritoneal fluid from women with advanced-stage endometriosis (p=0.027). Immunoreactivity of PR-B expression was significantly lower during the secretory phase than during the proliferative phase in endometrial tissues from control subjects (p<0.001). PR-B expression was significantly reduced in the eutopic endometrium (p=0.031) and ovarian endometrioma (p=0.036) from women with advanced-stage endometriosis compared with eutopic endometrium tissues from control subjects. CONCLUSION: Progesterone resistance in endometriosis may be caused by proinflammatory conditions in the pelvic peritoneal microenvironment.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Endometrium Receptors, Progesterone Tumor Necrosis Factor-alpha Adult Ascitic Fluid Case-Control Studies Cytokines Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Humans

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