THE EFFECTS OF ETANERCEPT AND CABERGOLINE ON ENDOMETRIOTIC IMPLANTS, UTERUS AND OVARIES IN RAT ENDOMETRIOSIS MODEL

Keleş CD, Cihan Deniz Keleş, Birol Vural, Vural B, Serdar Filiz, Filiz S, Vural F, Fisun Vural, Gülçin Gacar, Fatma Ceyla Eraldemir, Eraldemir FC, Kurnaz S, Sema Kurnaz
Journal of reproductive immunology · 2021 · vol. 146 , pp. 103340 · doi:10.1016/j.jri.2021.103340 · PMID:34139652 · W3171932476
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the effects of etanercept and cabergoline on endometriotic implants, uterus, and ovaries in a rat model of endometriosis.

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Abstract

The pathophysiology of endometriosis is still unknown and treatment options remain controversial. Searches focus on angiogenesis, stem cells, immunologic and inflammatory factors. This study investigated the effects of etanercept and cabergoline on ovaries, ectopic, and eutopic endometrium in an endometriosis rat model. This randomized, placebo-controlled, blinded study included 50 rats, Co(control), Sh(Sham), Cb(cabergoline), E(etanercept), and E + Cb(etanercept + cabergoline) groups. After surgical induction of endometriosis, 2nd operation was performed for endometriotic volume and AMH level. After 15 days of treatment: AMH level, flow cytometry, implant volume, histologic scores, immunohistochemical staining of ectopic, eutopic endometrium, and ovary were evaluated at 3rd operation. All groups had significantly reduced volume, TNF-α, VEGF, and CD 146/PDGF-Rβ staining of endometriotic implants comparing to the Sh group (p 0.05). E and E + Cb groups significantly decreased TNF-α staining in the ovary comparing to Sh, Co, and Cb groups (p < 0.05). All treatment groups had significantly higher AFC compared to the Sh group. CD25+ Cells' median percentage was significantly increased in the E + Cb group compared to Co, Sh, Cb, and E group. E + Cb group had a significantly higher CD5+ Cells' level than the Co group (p = 0.035). In conclusion; Etanercept and/or Cabergoline decreased volume, TNF-α, VEGF, and CD 146/PDGF-Rβ staining of the ectopic endometrial implant. E and E + Cb treatment decreased TNF-α levels in the ovary. E + Cb also increased peripheral blood CD25+ & CD5+ Cell's.

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Condition tags

endometriosis

MeSH descriptors

Cabergoline Endometriosis Endometrium Etanercept Animals Cabergoline Disease Models, Animal Drug Evaluation, Preclinical Drug Therapy, Combination Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Etanercept Female Humans Ovary Ovary

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