Regression of endometrial autografts in a rat model of endometriosis treated with etanercept

Mine Islimye, Islimye M, Sevtap Kılıç, Sevtap Kilic, Kilic S, Ebru Zülfikaroğlu, Ebru Zulfikaroglu, Topcu O, Onur Topcu, Zergeroglu S, Sema Zergeroglu, Sema Zergeroğlu, Sertaç Batıoğlu, Sertac Batioglu, Batioglu S
European journal of obstetrics, gynecology, and reproductive biology · 2011 · vol. 159(1) , pp. 184–189 · doi:10.1016/j.ejogrb.2011.06.029 · PMID:21741153 · W2160721484
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Etanercept treatment in a rat model of endometriosis led to the regression of endometrial autografts.

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Abstract

ObjectiveTo determine the efficacy of anti-tumor necrosis factor therapy (etanercept) for treating endometriosis in the rat endometriosis model.Study designA randomized, placebo-controlled, blinded study using rat endometriosis model. After the peritoneal implantation of endometrial tissue, twenty-eight Wistar female rats were randomized to two equal intervention groups: the control group and the etanercept-treated group. After measuring implant volume, pretreatment blood and peritoneal fluid samples were obtained. A vehicle treatment of 2 mL saline to the rats in control group and 0. 4 mg/kg etanercept SC once weekly were administered in the etanercept-treated group. After four weeks treatment period, the volumes and histopathological properties of the implants were evaluated. A scoring system was used to evaluate preservation of epithelia. Endometrial explants were evaluated immunohistochemically for tumor necrosis factor receptor type 2 (TNFR2). A scoring system was used to evaluate expression grade of TNFR2.ResultsThere was not a significant difference in spherical volume between control (131.0 (60.3-501.2)) and treatment groups (72.8 (31.2-149.6)) (p>0.025). There was a significant change in between the volumes of implants before and after treatment in etanercept group (p<0.05). At the end of the treatment significant differences among the groups were found in histopathological and immunohistochemical parameters (p<0.05) also histologic scores and HSCORES were decreased in the treatment group significantly (p<0.05).ConclusionThese results indicate that etanercept was found to effectively reduce the development of endometriosis in this experimental rat model.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Endometrium Immunoglobulin G Peritoneal Diseases Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha Animals Ascitic Fluid Atrophy Atrophy Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Etanercept Female Graft Survival

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