Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons

Barrier BF, Breton F Barrier, G Wright Bates, Bates GW, M Michelle Leland, Leland MM, D Alan Leach, D.A. Leach, Robinson RD, Randal D Robinson, Anthony M Propst, Propst AM
Fertility and Sterility · 2004 · vol. 81 , pp. 775–779 · doi:10.1016/j.fertnstert.2003.09.034 · PMID:15019808 · W2105596492
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This study investigated the efficacy of anti-tumor necrosis factor therapy in treating spontaneous endometriosis in baboons.

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Abstract

ObjectiveTo determine the efficacy of anti-tumor necrosis factor therapy (etanercept) for treating endometriosis in baboons.DesignA randomized, placebo-controlled, blinded study using the baboon endometriosis model.SettingSouthwest National Primate Research Center.Animal(s)Twelve female baboons with spontaneous peritoneal endometriosis.Intervention(s)Etanercept (n = 8) or sterile water (n = 4) was administered subcutaneously three times per week.Main outcome measure(s)After 8 weeks, the number, color, and surface area of peritoneal lesions was evaluated. Revised American Society for Reproductive Medicine staging was used.Result(s)A statistically significant decrease in red lesion surface area in the treatment group was observed. A trend toward a decrease in the absolute number of red lesions was noted in the treatment group. White and black lesion number and total surface area slightly increased in both groups but failed to achieve statistical significance. Endometriosis was diagnosed in 60% of captive-born baboons with primary infertility.Conclusion(s)These results indicate that etanercept effectively reduces the amount of spontaneously occurring active endometriosis in the baboon.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunoglobulin G Peritoneal Diseases Primate Diseases Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha Animals Endometriosis Endometriosis Endometriosis Etanercept Female Immunoglobulin G Papio Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Peritoneum Peritoneum Primate Diseases

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