Update on the treatment of endometriosis

Sung Hoon Kim, Hee Dong Chae, Chung-Hoon Kim, Chung‐Hoon Kim, Byung Moon Kang
Clinical and experimental reproductive medicine · 2013 · vol. 40(2) , pp. 55 · doi:10.5653/cerm.2013.40.2.55 · PMID:23875160 · W2154191550
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review summarizes current findings on endometriosis treatment, covering surgical outcomes for pain and infertility, and the efficacy of newer drugs like aromatase inhibitors, anti-tumor necrosis factor-alpha, and dienogest.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This review summarizes up-to-date evidence on treatment of endometriosis, focusing on outcomes of laparoscopic surgery for pelvic pain and infertility, and efficacy of newer medical therapies such as aromatase inhibitors, anti–tumor necrosis factor-α agents, and dienogest, largely using recent Cochrane reviews and clinical reports. For pelvic pain, the review reports that non-comparative surgery studies usually show symptom improvement but also substantial pain recurrence or re-operation rates (reported 24%–54%), with higher repetitive surgery risk in women under 30 years and in those with pelvic pain. Controlled and meta-analytic data cited suggest laparoscopic surgery can have an advantage over diagnostic laparoscopy only for pain at 6 and 12 months, and a Cochrane review on ovarian endometrioma indicates excisional surgery is associated with reduced recurrence for several pain outcomes compared with ablative surgery, while evidence about fertility after ovarian stimulation and IUI is insufficient. This paper is centrally about endometriosis — it reviews and synthesizes current evidence on surgical and medical treatment options and outcomes.

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Abstract

Endometriosis is defined as the presence of functional endometrial tissue outside the uterus, causing diverse progressive symptoms such as infertility, pelvic pain, and dysmenorrhea. Although endometriosis has been described since the 1800s, the mechanisms responsible for its pathogenesis and progression remain poorly understood. It is well established that endometriosis grows and regresses in an estrogen-dependent fashion and the disease can be effectively cured by definitive surgery. However, prolonged medical therapy may be needed in most of the cases since conservative surgery is usually performed especially in young women. This treatment modality is often associated with only partial relief and/or recurrence of the disease. In the present review, up-to-date findings on the treatment of endometriosis will be briefly summarized. The outcomes of surgery in patients with endometriosis will be reviewed in terms of pelvic pain relief as well as infertility treatment largely based on recent Cochrane reviews and clinical reports. The efficacy of newer drugs including aromatase inhibitor, anti-tumor necrosis factor-alpha, and dienogest will be also reviewed based on recent clinical studies.

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Condition tags

endometriosisdysmenorrheainfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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