The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cells
Lab / animal
OA: closed
CC0
⤵ 26 in-corpus citations
AI-generated summary
This study investigated the role of progesterone receptor isoform B (PR-B) in immortalized endometrial stromal cells and found that its knockdown promotes cell proliferation.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
The knockdown of PR-B by siRNA resulted in a significant increase in proliferation in an immortalized endometrial stromal cell line. This suggests that PR-B knockdown might be responsible, at least in part, for increased proliferation and resistance to apoptosis as seen in the eutopic and ectopic endometrium of women with endometriosis.
My notes (saved in your browser only)
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (21)
- Cell proliferation is increased in the endometrium of women with endometriosis via openalex
- Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780 via openalex
- Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex
- Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large? via openalex
- Progesterone receptor isoform A but not B is expressed in endometriosis via openalex
- Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells via openalex
- Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis via openalex
- Reduction of apoptosis and proliferation in endometriosis via openalex
- Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis via openalex
- W2109801386 via openalex
- W4211081176 via openalex
- W1569704074 via openalex
- W6658221620 via openalex
- W1972848037 via openalex
- W2003778314 via openalex
- W2011025558 via openalex
- W2038507723 via openalex
- W2065643273 via openalex
- W2092268704 via openalex
- W2108004598 via openalex
- W2109525253 via openalex
Cited by (26)
- From Retrograde Menstruation to Endometrial Determinism and a Brave New World of "Root Treatment" of Endometriosis: Destiny or a Fanciful Utopia? 2023
- Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics 2023
- Aberrant epigenetic regulation of estrogen and progesterone signaling at the level of endometrial/endometriotic tissue in the pathomechanism of endometriosis 2022
- The gut microbiota: a double-edged sword in endometriosis† 2022
- Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis 2021
- Dioxin and endometriosis: a new possible relation based on epigenetic theory 2019
- Progesterone resistance in endometriosis: origins, consequences and interventions 2017
- Altered retinoid signaling compromises decidualization in human endometriotic stromal cells 2017
- Retinoid Metabolism in Endometriosis 2017
- Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells 2015
- Correlation between dioxin and endometriosis: an epigenetic route to unravel the pathogenesis of the disease 2015
- Small RNA molecules in endometriosis: pathogenesis and therapeutic aspects 2014
- Epigenetic background of the most common non-oncologic gynecological diseases 2014
- Epigenetics in Endometriosis 2014
- The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis 2014
- Epigenetic aberration of gene expression in endometriosis 2013
- The Epigenetics of Endometriosis 2012
- Etude phénotypique des cellules endométriosiques profondes 2012
- Progesterone Resistance and Targeting the Progesterone Receptors: A Therapeutic Approach to Endometriosis 2012
- Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line 2012
- Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action 2011
- Aberrant DNA methylation status of endometriosis: epigenetics as the pathogenesis, biomarker and therapeutic target 2011
- Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis 2011
- Antiproliferative effects of anastrozole, methotrexate, and 5-fluorouracil on endometriosis in vitro and in vivo 2010
- Altered retinoid uptake and action contributes to cell survival in endometriosis 2010
- Disrupted cell cycle control in cultured endometrial cells from patients with endometriosis harboring the progesterone receptor polymorphism PROGINS 2009
Source provenance
- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:05:01.267406+00:00
- unpaywall
- last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0
· commercial use OK