Cell proliferation is increased in the endometrium of women with endometriosis

Mary Wingfield, M Wingfield, A. MacPherson, Macpherson A, D L Healy, David Healy, Healy DL, Peter A. W. Rogers, P A Rogers
Fertility and sterility · 1995 · vol. 64(2) , pp. 340–346 · doi:10.1016/s0015-0282(16)57733-4 · PMID:7542208 · W2405990161
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This study investigated cell proliferation in the endometrium of women with endometriosis, finding an increase in proliferation.

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Abstract

ObjectiveTo compare the proliferation of endothelial, epithelial, and stromal cells in the endometrium of women with endometriosis and normal controls.DesignProliferating cells were identified using the monoclonal antibody antiproliferating cell nuclear antigen. A second antibody (CD34) was used to identify endothelial cells (ECs).SettingUniversity Department of Obstetrics and Gynaecology.PatientsWomen with laparoscopically proven endometriosis, n = 30. Controls were women with a normal pelvis at laparoscopy performed for tubal sterilization or for infertility due to a male factor, n = 27.Main outcome measuresEndothelial cells: proliferative index. Epithelial and stromal cells: semi-quantitative immunostaining score.ResultsThe mean EC proliferative index was significantly greater in those with endometriosis compared with controls. This difference was most marked during the proliferative phase of the menstrual cycle. Proliferative phase epithelial and stromal cells demonstrated significantly higher immunostaining scores in endometriosis patients than in controls.ConclusionsWe have demonstrated increased numbers of proliferating ECs as well as epithelial and stromal cells in proliferative phase endometrium of women with endometriosis. This suggests that the endometrium of these women might have an enhanced ability to implant and survive in ectopic locations.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Antigens, CD Antigens, CD Antigens, CD34 Cell Division Endometriosis Endometrium Female Humans Proliferating Cell Nuclear Antigen Proliferating Cell Nuclear Antigen

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (50)

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