Curcumin in the Management of Endometriosis
Curcumin, a compound used in Asian folk medicine, is highlighted for its anti-inflammatory properties in managing endometriosis due to hormonal resistance and immune dysregulation.
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This paper chapter discusses endometriosis as an inflammatory disorder involving immune dysregulation and altered sex steroid signaling that contributes to hormonal resistance, lesion survival and proliferation, and infertility. It reviews how commonly used hormonal therapies (synthetic progestins, GnRH agonists, and danazol) often have limited efficacy, may be counterproductive to fertility, and can cause systemic side effects due to suppression of endogenous steroid hormones. It highlights curcumin (diferuloylmethane), described as a long-used anti-inflammatory folk medicine in Asian countries for this condition, framing its potential role in management. This paper is centrally about endometriosis — it specifically focuses on curcumin as an anti-inflammatory approach in endometriosis, within a discussion of immune dysregulation and hormonal resistance.
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