Endometriosis impairs glycogen synthesis in human endometrium.

Shingo Ishihara, S Ishihara, Y Taketani, Minoru Mizuno, M Mizuno
International journal of fertility · 1992 · vol. 36(5) , pp. 287–90 · PMID:1683657 · W2403285814
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Endometriosis significantly reduces endometrial glycogen content and glycogen synthetase activity during the secretory phase, potentially explaining endometriosis-associated infertility.

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Abstract

Glycogen content in endometrium with endometriosis was about half of that without endometriosis at the secretory phase, whereas no difference was found in the proliferative phase. The activity of glycogen synthetase in endometrium with endometriosis was reduced to 25% and 23% of that without endometriosis in the late proliferative and midsecretory phase, respectively. The activity of glycogen phosphorylase was also significantly lower in endometrium with endometriosis in the late proliferative phase. However, the activity increased conspicuously in the midsecretory phase, and thus there was no difference in activity in endometrium with or without endometriosis. The observed lowered capacity of glycogen synthesis may lead to understanding the mechanism of infertility associated with endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometrial Neoplasms Endometriosis Endometrium Glycogen Adult Endometrial Neoplasms Endometriosis Endometrium Female Glycogen Glycogen Synthase Glycogen Synthase Humans Menstrual Cycle Menstrual Cycle Phosphorylases Phosphorylases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (7)

SciLite annotations

chemicals 3
glycogen glycogen glycogen
organisms 1
human

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