Endometriosis impairs glycogen synthesis in human endometrium
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Endometriosis significantly reduces endometrial glycogen content and glycogen synthetase activity during the secretory phase, potentially explaining endometriosis-associated infertility.
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Abstract
Glycogen content in endometrium with endometriosis was about half of that without endometriosis at the secretory phase, whereas no difference was found in the proliferative phase. The activity of glycogen synthetase in endometrium with endometriosis was reduced to 25% and 23% of that without endometriosis in the late proliferative and midsecretory phase, respectively. The activity of glycogen phosphorylase was also significantly lower in endometrium with endometriosis in the late proliferative phase. However, the activity increased conspicuously in the midsecretory phase, and thus there was no difference in activity in endometrium with or without endometriosis. The observed lowered capacity of glycogen synthesis may lead to understanding the mechanism of infertility associated with endometriosis.
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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
Cited by (7)
- Theories of endometriosis 2001
- Differential expression and localization of de-novo synthesized endometriotic haptoglobin in endometrium and endometriotic lesions 2000
- Is endometriosis an endometrial disease? 2000
- Endometrial vascular and glandular expression of integrin alpha(v)beta3 in women with and without endometriosis 1998
- Angiogenesis: a new theory for endometriosis 1998
- Cell proliferation is increased in the endometrium of women with endometriosis 1995
- Comparison of cytokine levels and embryo toxicity in peritoneal fluid in infertile women with untreated or treated endometriosis 1992
SciLite annotations
chemicals 3
glycogen
glycogen
glycogen
organisms 1
human
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- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
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- pubmed
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