Family trait analysis: a case-control study of 43 women with endometriosis and their best friends

K Lamb, Lamb K, Karen E. Lamb, R G Hoffmann, Hoffmann RG, Raymond G. Hoffmann, T R Nichols, Nichols TR, Thomas Nichols
American journal of obstetrics and gynecology · 1986 · vol. 154(3) , pp. 596–601 · doi:10.1016/0002-9378(86)90608-3 · PMID:3953705 · W2052074487
Observational OA: closed CC0 ⤵ 79 in-corpus citations
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This case-control study examined endometriosis risk by comparing the prevalence of associated symptoms and conditions in women with endometriosis and their best friends.

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Abstract

Analyses of lineage patterns show that for 43 women with endometriosis who reported that other family members have the disease, the vast majority of these familial cases involve the maternal lineage (79% to 93%). Of these women 34.9% of their mothers and 21.2% of their sisters were affected. With use of these rates, expected rates for first-degree relatives in a general population of women with endometriosis were determined. These rates were 6.2% and 3.8%, respectively; in combination, these rates yield an overall risk of 4.9% for first-degree relatives. Prior studies estimated this overall risk to be 6.9%; however, z scores determined that these rates do not differ statistically. Rates for second-degree maternal relatives are reported for grandmothers and aunts (0.4% compared to 3.1%, respectively), thus expanding results of former studies. In combination, an overall risk of 1.9% is estimated for second-degree relatives, as measured.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Uterine Neoplasms Adult Adult Consanguinity Consanguinity Endometriosis Endometriosis Female Female Humans Humans Socioeconomic Factors Socioeconomic Factors Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (50)

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