Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis

Maeda N, Nagamasa Maeda, Chiaki Izumiya, Izumiya C, Yamamoto Y, Yorito Yamamoto, Hiroyoshi Oguri, Oguri H, Kusume T, Tomoaki Kusume, Takao Fukaya, Fukaya T
Fertility and sterility · 2002 · vol. 77(2) , pp. 297–302 · doi:10.1016/s0015-0282(01)02964-8 · PMID:11821086 · W2025820846
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-12 ⓘ

This study investigated natural killer cells and found increased killer inhibitory receptor KIR2DL1 expression in women diagnosed with pelvic endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text ⓘ

This study examined natural killer (NK) cells from women with pelvic endometriosis to assess expression of the killer inhibitory receptor KIR2DL1, using immunologic profiling of NK-cell populations. The authors report increased KIR2DL1 expression among NK cells in the women with pelvic endometriosis compared with controls, supporting the idea of altered immune tolerance mechanisms. A key limitation is that the excerpted information does not specify detailed sample size, experimental controls, or how KIR2DL1 expression was quantified, which constrains evaluation of robustness. This paper is centrally about endometriosis — it specifically analyzes increased KIR2DL1 expression on NK cells in women with pelvic endometriosis.

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Abstract

ObjectiveTo investigate the host immunologic response to endometriosis in terms of killer inhibitory receptor (KIR) expression by natural killer (NK) cells.DesignCase-control study of immunologic markers.SettingUniversity hospital.Patient(s)We compared cells from Japanese women with laparoscopically diagnosed endometriosis to cells from 40 women with other laparoscopic diagnoses.Intervention(s)Peripheral venous blood sampling and laparoscopic peritoneal fluid collection.Main outcome measure(s)Flow cytometry was used to assess expression of KIR by NK cells in the cell samples.Result(s)The percentage of cells that expressed KIR2DL1 among NK (KIR2DL1(+)NK) cells in peritoneal fluid and peripheral blood was significantly higher in women with endometriosis than in controls. The proportion of KIR2DL1(+)NK cells in peripheral blood NK cells before and 1 month after laparoscopic surgery did not differ significantly.Conclusion(s)The proportion of KIR2DL1(+)NK cells was increased in peritoneal fluid and peripheral blood in women with endometriosis; this difference is probably related to NK cell suppression in endometriosis. This increase in KIR2DL1 expression by NK cells may represent a risk factor in the pathogenesis of endometriosis.
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WEKO3 アイテム Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis http://hdl.handle.net/10126/2990 http://hdl.handle.net/10126/2990198575ad-71d3-4ded-a7a2-b1af75bdc32c | 名前 / ファイル | ライセンス | アクション | |---|---|---| | FerSte7702297maeda.pdf (69.8 kB) | | | | FerSte7702297Tables.pdf (43.2 kB) | | | アイテムタイプ | 学術雑誌論文 / Journal Article(1) | ||||| |---|---|---|---|---|---|---| | 公開日 | 2009-07-23 | ||||| | タイトル | |||||| | タイトル | Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis | ||||| | 言語 | en | ||||| | 言語 | |||||| | 言語 | eng | ||||| | キーワード | |||||| | 言語 | en | ||||| | 主題Scheme | Other | ||||| | 主題 | killer inhibitory receptor | ||||| | キーワード | |||||| | 言語 | en | ||||| | 主題Scheme | Other | ||||| | 主題 | natural killer cells | ||||| | キーワード | |||||| | 言語 | en | ||||| | 主題Scheme | Other | ||||| | 主題 | immunotolerance | ||||| | 資源タイプ | |||||| | 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | ||||| | 資源タイプ | journal article | ||||| | 著者 | Maeda, Nagamasa × Maeda, Nagamasa× Izumiya, Chiaki× Yamamoto, Yorito× Oguri, Hiroyoshi× Kusume, Tomoaki× Fukaya, Takao | ||||| | 書誌情報 | en : Fertility and sterility 巻 77, 号 2, p. 297-302, 発行日 2002-02 | ||||| | ISSN | |||||| | 収録物識別子タイプ | ISSN | ||||| | 収録物識別子 | 00150282 | ||||| | 書誌レコードID | |||||| | 収録物識別子タイプ | NCID | ||||| | 収録物識別子 | AA00645034 | ||||| | DOI | |||||| | 識別子タイプ | DOI | ||||| | 関連識別子 | 10.1016/S0015-0282(01)02964-8 | ||||| | 権利 | |||||| | 権利情報 | The original publication is available at www.sciencedirect.com | ||||| | フォーマット | |||||| | 内容記述タイプ | Other | ||||| | 内容記述 | application/pdf | ||||| | 出版者 | |||||| | 出版者 | Elsevier |

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Killer Cells, Natural Lectins, C-Type Receptors, Immunologic Adult Antigens, CD Antigens, CD Antigens, CD Ascitic Fluid Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Endometriosis Female Flow Cytometry Humans Japan Killer Cells, Natural Killer Cells, Natural

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