Role of NK Cells in Endometriosis

Nagamasa Maeda
In: Endometriosis · 2014 · pp. 49–60 · doi:10.1007/978-4-431-54421-0_5 · W86720406
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This article discusses how impaired natural killer cell activity, potentially due to interactions with HLA-G from endometrial tissue, may contribute to endometriosis pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper examines impaired natural killer (NK) cell activity in women with endometriosis, focusing on whether changes in HLA-G expression in eutopic endometrium across the menstrual cycle could provide a mechanism for reduced NK-mediated clearance of cells in the peritoneal cavity. It reports that HLA-G is detectable in eutopic endometrium only during the menstrual phase and also appears on cells in peritoneal fluid during that same phase, consistent with the idea that retrograde menstruation introduces HLA-G–expressing tissue that can inhibit NK cells. A key limitation is that the work is framed as a discussion of pathogenesis and intraperitoneal NK receptor–ligand interactions rather than presenting new quantitative functional measurements. This paper is centrally about endometriosis — it proposes an HLA-G–mediated mechanism linking menstrual HLA-G expression to impaired peritoneal NK cell activity.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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