In vitro lymphocyte activity in women with endometriosis—an altered immune response?
article
OA: closed
CC0
⤵ 35 in-corpus citations
AI-generated summary
This study investigated lymphocyte activity in women with endometriosis, revealing an altered immune response within this patient group.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
ObjectiveTo determine the possible role of the immune system in the pathogenesis of endometriosis.DesignThe lymphocyte proliferative response in the presence of autologous endometrial cells was assayed by tritiated thymidine incorporation.SettingPatients were recruited from a university outpatient clinic.Main outcome measureTo determine the lymphocyte proliferative response to endometrium in controls and patients with endometriosis.ParticipantsTwenty patients with endometriosis and 26 control women were studied.ResultsThe lymphocyte proliferative response in the presence of autologous endometrium was significantly lower in women with endometriosis when compared with controls.ConclusionThis study indicates that an altered lymphocyte/endometrial cell relationship is operational in women with endometriosis and may contribute to the pathogenesis of the disease.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (31)
- Antiendometrial Antibodies in Patients With Endometriosis via openalex
- Autoantibodies associated with endometriosis: Can their detection predict presence of the disease? via openalex
- Autoimmunity to endometrium and ovary in endometriosis. via openalex
- Autoimmunity to Endometrium and Ovary in Endometriosis via openalex
- Characterization of leukocyte subpopulations in the peritoneal fluid of women with endometriosis via openalex
- Deficient cellular immunity in endometriosis via openalex
- Effect of Peritoneal Fluid From Endometriosis Patients on Endometrial Stromal Cell Proliferation In Vitro via openalex
- Endometrial antigens involved in the autoimmunity of endometriosis via openalex
- Experimental evidence for failure to implant as a mechanism of infertility associated with endometriosis via openalex
- Immunologic Aspects of Human Endometriosis via openalex
- Interleukin-1: a possible role in the infertility associated with endometriosis via openalex
- Interleukin‐1: A possible role in the infertility associated with endometriosis via openalex
- Local autoimmunity in mild endometriosis. via openalex
- Lymphocyte activity in the presence of peritoneal fluid from fertile women and infertile women with and without endometriosis via openalex
- Pelvic macrophages in normal and infertile women: The role of patent tubes via openalex
- Peritoneal fluid in patients with and without endometriosis: Prostanoids and macrophages and their effect on the spermatozoa penetration assay via openalex
- Peritoneal fluid prostaglandins and prostanoids in women with endometriosis, chronic pelvic inflammatory disease, and pelvic pain via openalex
- Peritoneal fluid volume, estrogen, progesterone, prostaglandin, and epidermal growth factor concentrations in patients with and without endometriosis via openalex
- Retrograde menstruation in healthy women and in patients with endometriosis. via openalex
- W6652686215 via openalex
- W2018372782 via openalex
- W6719973196 via openalex
- W2046223270 via openalex
- W141728048 via openalex
- W104614849 via openalex
- W2409202770 via openalex
- W2477008945 via openalex
- W2894942498 via openalex
- W6603902953 via openalex
- W6604284578 via openalex
- W6628680024 via openalex
Cited by (34)
- Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis 2024
- Myeloid-derived suppressor cells: A new emerging player in endometriosis 2023
- Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target 2021
- Avaliação das células iNKT em pacientes com endometriose 2019
- Immunological aspects of endometriosis: a review. 2015
- Investigation of serum proteome alterations in human endometriosis 2014
- Role of NK Cells in Endometriosis 2014
- Roles of regulatory T cells in endometriosis-associated infertility 2014
- Female Infertility and Free Radicals: Potential Role in Endometriosis and Adhesions 2012
- Endometriosis: Disease Classification and Behavior 2011
- Inflammation and Endometriosis 2011
- Lymphocytes in Endometriosis 2010
- Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis 2010
- Decreased human leukocyte antigen–DR expression in the lipid raft by peritoneal macrophages from women with endometriosis 2007
- Killer Immunoglobulin‐like Receptor and Human Leukocyte Antigen Expression as Immunodiagnostic Parameters for Pelvic Endometriosis 2006
- Female Infertility and Free Radicals: Potential Role in Adhesions and Endometriosis 2006
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- Human leukocyte antigen expression by peritoneal macrophages from women with pelvic endometriosis is depressed but coordinated with costimulatory molecule expression 2005
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- Coordinated but depressed expression of human leukocyte antigen-DR, intercellular adhesion molecule-1, and CD14 on peritoneal macrophages in women with pelvic endometriosis 2003
- Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis 2002
- Manejo de la endometriosis mínima y leve. 2002
- New considerations for the pathogenesis of endometriosis 2002
- Aberrant expression of intercellular adhesion molecule-1 and killer inhibitory receptors induces immune tolerance in women with pelvic endometriosis 2002
- Expression of AhR and ARNT mRNA in Cultured Human Endometrial Explants Exposed to TCDD 2001
- Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis 1999
- Immunological Aspects of Endometriosis 1999
- Immunomodulation in women with endometriosis receiving GnRH agonist 1997
- Endometriosis-associated infertility 1997
- Clinical relevance of the baboon as a model for the study of endometriosis 1997
- Decreased amounts of antibodies to 22 and 18 kDa antigens in the peritoneal fluid of patients with endometriosis 1996
- Immunological aspects of endometriosis 1996
- Human Peritoneal Macrophage and T Lymphocyte Populations in Mild and Severe Endometriosis 1995
- 8 Endometriosis-associated infertility 1993
Source provenance
- europepmc
- last seen: 2026-08-19T06:08:28.815611+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:11:44.647872+00:00
- unpaywall
- last seen: 2026-08-19T06:23:00.919175+00:00
License: CC0
· commercial use OK