Human leukocyte antigen expression by peritoneal macrophages from women with pelvic endometriosis is depressed but coordinated with costimulatory molecule expression

Tomoaki Kusume, Kusume T, Nagamasa Maeda, Maeda N, Chiaki Izumiya, Izumiya C, Yorito Yamamoto, Yamamoto Y, Hayashi K, Kazutoshi Hayashi, Hiroyoshi Oguri, Oguri H, Yoshiko Nishimori, Nishimori Y, Fukaya T, Takao Fukaya
Fertility and Sterility · 2005 · vol. 83(4) , pp. 1232–1240 · doi:10.1016/j.fertnstert.2004.11.039 · PMID:15831297 · W2051556406
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Peritoneal macrophages from women with endometriosis exhibit reduced human leukocyte antigen expression, which is coordinated with alterations in costimulatory molecule expression.

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Abstract

ObjectiveTo investigate the macrophage response in endometriosis, we determined expression of human leukocyte antigen (HLA)-ABC, HLA-DR, and their costimulatory molecules by peritoneal fluid (PF) macrophages.DesignCase-control study of immunologic markers.SettingUniversity hospital.Patient(s)We compared 38 Japanese women with endometriosis with 59 control subjects who were given other laparoscopic diagnoses.Intervention(s)Venipuncture and laparoscopic peritoneal fluid collection.Main outcome measure(s)Expression of HLA-ABC, HLA-DR, CD54, CD40, CD58, CD80, and CD86 by peripheral blood (PB) monocytes and PF macrophages was quantitated as mean fluorescence intensities by flow cytometry. Expression of each marker on PF macrophages was divided by that on PB monocytes as an index of macrophage activation (macrophage activation ratio).Result(s)In women with endometriosis, PF macrophages showed significant positive correlations between expression of HLA-ABC and other costimulatory molecules and also between HLA-DR and their costimulatory molecules. However, expression of HLA-ABC and DR by PF macrophages, and also their activation ratios, were significantly lower than in controls.Conclusion(s)Coordination with costimulatory molecules but relatively low expression of HLA-ABC and HLA-DR indicates a positive but limited immune response (antigen presentation) to events in the peritoneal cavity in women with endometriosis. This may induce immune tolerance to implanted or metaplastic endometrial tissue.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Endometriosis HLA Antigens Macrophages, Peritoneal Adult Antigen Presentation Antigen Presentation Antigens, CD Antigens, CD B7-1 Antigen B7-1 Antigen B7-2 Antigen Biomarkers Case-Control Studies CD40 Antigens CD40 Antigens CD58 Antigens CD58 Antigens Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (12)

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