Production of Interleukins 1β, 6 and 8 and Tumor Necrosis Factor Alpha in Separated and Cultured Endometrial and Endometriotic Stromal and Epithelial Cells

A Bergqvist, Agneta Bergqvist, H Nejaty, Hedieh Nejaty, B Fröysa, Berit Fröysa, C Bruse, Christine Bruse, Magdalena Carlberg, M Carlberg, Peter Sjöblom, P Sjöblom, Olle Söder, O Söder
Gynecologic and obstetric investigation · 2000 · vol. 50(1) , pp. 1–6 · doi:10.1159/000010269 · PMID:10895019 · W1988457130
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study measured IL-1β, IL-6, IL-8, and TNF-α production in cultured human endometrial and endometriotic stromal and epithelial cells, finding IL-8 present in all samples and IL-1β/TNF-α more in stromal than epithelial cells.

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Abstract

The production of IL-1beta, IL-6, IL-8 and TNF-alpha was studied in short-time culture of separated stromal and epithelial cells. The cytokine secretion into culture medium was analyzed using immunoassay to evaluate the cytokine protein levels and bioassay to assess the bioactivity of the cytokines. Tissue samples of endometrium and ovarian endometriomas were obtained from 4 patients operated on for clinical reasons. Only IL-8 was found in all samples. IL-1beta and TNF-alpha were detected in the culture medium from most stromal cell samples, but in fewer media from epithelial cell samples. IL-6 was measurable in a few medium samples. Few of the samples displayed a bioactivity. There was no obvious difference between endometrium and endometriotic cell samples besides the production of IL-8 that seems to be lower in endometriotic tissue.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Interleukin-1 Interleukin-6 Interleukin-8 Tumor Necrosis Factor-alpha Adult Cells, Cultured Culture Media, Conditioned Endometriosis Endometrium Epithelial Cells Epithelial Cells Female Humans Immunoassay Interleukin-1 Interleukin-6 Interleukin-8 Middle Aged

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