Interleukin 1β, interleukin-6, and tumor necrosis factor-α in endometriotic tissue and in endometrium

Agneta Bergqvist, A Bergqvist, Bergqvist A, C Bruse, Bruse C, Christine Bruse, Carlberg M, M Carlberg, Magdalena Carlberg, K Carlström, Kjell Carlström, Carlström K
Fertility and Sterility · 2001 · vol. 75(3) , pp. 489–495 · doi:10.1016/s0015-0282(00)01752-0 · PMID:11239529 · W1994760822
article OA: closed CC0 ⤵ 131 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the presence of interleukin 1β, interleukin-6, and tumor necrosis factor-α in endometriotic tissue and endometrium.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo compare the levels of IL-1beta, IL-6, and TNFalpha in endometriotic tissue and in endometrium from women with endometriosis and healthy controls.DesignOpen.SettingDepartment of Obstetrics and Gynecology at a university hospital.Patient(s)Twenty-six women with endometriosis and 22 controls operated on for clinical indications.Intervention(s)ELISA in homogenized tissue samples collected during surgery.Main outcome measure(s)Levels of IL-1beta, IL-6, and TNFalpha in tissue homogenates.Result(s)The three types of tissue differed significantly with respect to all three cytokines. Endometriotic tissue had significantly higher concentrations of IL-1beta than endometrium from both patients with endometriosis and healthy controls. Both endometriotic tissue and endometrium from patients had significantly higher concentrations of IL-6, and endometriotic tissue had significantly lower concentration of TNFalpha than did endometrium from controls. IL-1beta showed a cycle phase dependence that was significant in endometrium from patients, being higher in the secretory than in the follicular phase. IL-1beta was significantly higher in endometrioma than in lesions of other localizations. Concentrations of IL-1beta and IL-6 were positively correlated in endometriotic tissue and in endometrium from controls. No other significant correlations were found.Conclusion(s)This study has shown a significant production of IL-1beta, IL-6, and TNFalpha in endometriotic tissue and endometrium, with significant differences between the tissue types, indicating a deviating cytokine pattern in both endometriotic tissue and endometrium from women with endometriosis compared with that from healthy controls.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Interleukin-1 Interleukin-6 Tumor Necrosis Factor-alpha Endometriosis Endometrium Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-1 Interleukin-6 Menstrual Cycle Ovarian Diseases Ovarian Diseases Tumor Necrosis Factor-alpha

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (50)

Source provenance

europepmc
last seen: 2026-07-25T06:15:30.875455+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:30.513821+00:00
License: CC0 · commercial use OK