Immunopathology of the Female Reproductive Tract and Mammary Gland

The female reproductive tract (FRT) has unique requirements for regulation of immune protection in pregnant and non-pregnant states. During the non-pregnant state, the ovary creates a protective environment for the ova by controlling the normal inflammatory reactions that occur during cycling of the ovary, and a modified mucosal immunity protects the remainder of the FRT from invading microorganisms. During pregnancy, to ensure that the fetus or placental tissues are not rejected as being “foreign”, the placenta has creative mechanisms to down-regulate antigen specific immunity and selective aspects of innate immunity. Within the metrial gland, the uterine natural killer cell (uNK) works cooperatively with the trophoblast to establish tolerance to the fetal antigens. This chapter will cover the animal models used to study the pathogenesis of diseases of women in which immune dysregulation of the FRT is implicated, including premature ovarian failure, polycystic ovary syndrome, endometriosis, preeclampsia, and recurrent miscarriages. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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The authors would like to thank Dr. Sue Edelstein for her expert assistance with the creation of the excellent drawings. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2017 Springer International Publishing AG About this chapter Cite this chapter Picut, C.A., Dixon, D., de Rijk, E.P.C.T. (2017). Immunopathology of the Female Reproductive Tract and Mammary Gland. In: Parker, G. (eds) Immunopathology in Toxicology and Drug Development. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-47385-7_11 Download citation DOI: https://doi.org/10.1007/978-3-319-47385-7_11 Published: Publisher Name: Humana Press, Cham Print ISBN: 978-3-319-47384-0 Online ISBN: 978-3-319-47385-7 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)