{"paper_id":"bf528cad-83f5-4355-a45e-7dbe6b990173","body_text":"Abstract\nThe female reproductive tract (FRT) has unique requirements for regulation of immune protection in pregnant and non-pregnant states. During the non-pregnant state, the ovary creates a protective environment for the ova by controlling the normal inflammatory reactions that occur during cycling of the ovary, and a modified mucosal immunity protects the remainder of the FRT from invading microorganisms. During pregnancy, to ensure that the fetus or placental tissues are not rejected as being “foreign”, the placenta has creative mechanisms to down-regulate antigen specific immunity and selective aspects of innate immunity. Within the metrial gland, the uterine natural killer cell (uNK) works cooperatively with the trophoblast to establish tolerance to the fetal antigens. This chapter will cover the animal models used to study the pathogenesis of diseases of women in which immune dysregulation of the FRT is implicated, including premature ovarian failure, polycystic ovary syndrome, endometriosis, preeclampsia, and recurrent miscarriages.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nAbrahams VM, Mor G (2005) Toll-like receptors and their role in the trophoblast. Placenta 26(7):540–547. doi:10.1016/j.placenta.2004.08.010\nAbrahams VM, Kim YM, Straszewski SL, Romero R, Mor G (2004a) Macrophages and apoptotic cell clearance during pregnancy. Am J Reprod Immunol 51(4):275–282. doi:10.1111/j.1600-0897.2004.00156.x\nAbrahams VM, Straszewski-Chavez SL, Guller S, Mor G (2004b) First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. 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Immunopathology of the Female Reproductive Tract and Mammary Gland. In: Parker, G. (eds) Immunopathology in Toxicology and Drug Development. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-47385-7_11\nDownload citation\nDOI: https://doi.org/10.1007/978-3-319-47385-7_11\nPublished:\nPublisher Name: Humana Press, Cham\nPrint ISBN: 978-3-319-47384-0\nOnline ISBN: 978-3-319-47385-7\neBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)","source_license":"CC0","license_restricted":false}