Immunology: Bone marrow-derived cell populations in uterine and ectopic endometrium
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This study found that both uterine and ectopic endometrium contain diverse bone marrow-derived immune cells, with ectopic endometrium showing similar cell populations to uterine endometrium but lacking cyclical changes.
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Abstract
Uterine endometrium contains numerous bone marrow-derived cells. The spectrum of cell types is different from that of any other tissue, and the differences in endometrium from women with endometriosis may reflect a different endometrial phenotype in these women. The cell types of bone marrow origin found in ectopic endometrium may indicate the degree of differentiation of the tissue. It was found that, in normal endometrium, the CD45+ cell population comprised T cells, macrophages, CD56+ large granular lymphocytes, some CD16+ cells and a few B cells. Changes in these cell populations during the menstrual cycle were similar in endometrium from both controls and patients with endometriosis, and resembled that reported previously by others. In ectopic endometrium, the frequency of CD45+ cells remained within the same range as that of uterine endometrium but without any obvious pattern of change during the menstrual cycle. CD56+ large granular lymphocytes, an immune cell type characteristic of uterine endometrium, were also found in ectopic endometrium. Our results indicate that ectopic endometrium, as well as comprising both glandular and stromal cells, contains bone marrow-derived cell populations similar to those of uterine endometrium. This suggests that the same processes of cell migration and/or differentiation occur in ectopic and uterine endometrium.
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Cited by (16)
- Clinical consequences of defective decidualization 2021
- The Genetic-Epigenetic Pathophysiology of Endometriosis: A Surgeon’s View 2020
- Pathogenesis of endometriosis: the genetic/epigenetic theory 2018
- Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis 2016
- Endometrial biomarkers for the non-invasive diagnosis of endometriosis 2016
- Characterization of Uterine <scp>NK</scp> Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis 2014
- Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis 2011
- Lymphocytes in Endometriosis 2010
- Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis 2009
- Microanatomy and function of the eutopic endometrium in women with endometriosis 2008
- Changes in the T-helper cytokine profile and in lymphocyte activation at the systemic and local levels in women with endometriosis 2005
- Cytokine Network of Eutopic and Ectopic Endometrium in Women with Adenomyosis 2002
- Spatially Heterogenous Expression of Aromatase P450 through Promoter II Is Closely Correlated with the Level of Steroidogenic Factor-1 Transcript in Endometrioma Tissues 2002
- Interleukin 1β, interleukin-6, and tumor necrosis factor-α in endometriotic tissue and in endometrium 2001
- IMMUNOLOGY AND ENDOMETRIOSIS 1997
- In vitro culture of endometrial stromal and gland cells as a model for endometriosis: The effect of peritoneal fluid on proliferation 1997
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- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
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