Microanatomy and function of the eutopic endometrium in women with endometriosis

Moamar Al‐Jefout, Natsuko Tokushige, Alison J. Hey‐Cunningham, Frank Manconi, Cecilia Ng, L. Schulke, Marina Berbic, Robert Markham, Fraser Is
In: Expert Review of Obstetrics & Gynecology · 2008 · vol. 4(1) , pp. 61–79 · doi:10.1586/17474108.4.1.61 · W1980752829
article OA: closed CC0 ⤵ 13 in-corpus citations
View on OpenAlex View at publisher

Abstract

Endometriosis is a disease that still presents many puzzles to clinicians and basic research scientists. Until recently, it has been regarded as a condition that arises when normal endometrium adheres to the peritoneal surface and then grows into an ‘inflammatory’ lesion, which adversely influences local reproductive tract function and causes pain. It is now becoming clear that the endometrium within the uterus in these women differs significantly in function from ‘normal’, and that these anomalies probably precede the development of classical ectopic endometriotic lesions. However, the etiology and mechanisms by which endometriosis arises are still far from certain. This review attempts to address the extensive, but fragmented, evidence that demonstrates widespread molecular disturbances in endometrial function and microstructure underlying this complex condition. The review also addresses some of the novel concepts that are being raised by these exciting new discoveries.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (13)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK