Increased expression of endoglin in the eutopic endometrium of women with endometriosis

Sung Hoon Kim, S H Kim, Kim SH, Y. M. Choi, Young Min Choi, Choi YM, H D Chae, Chae HD, Hee Dong Chae, K R Kim, Kim KR, Kyu Rae Kim, Kim CH, C. H. Kim, Chung Hoon Kim, B M Kang, Kang BM, Byung Moon Kang
Fertility and Sterility · 2001 · vol. 76(5) , pp. 918–922 · doi:10.1016/s0015-0282(01)02733-9 · PMID:11704111 · W2101957351
article OA: bronze CC0 ⤵ 26 in-corpus citations
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This paper investigated endoglin expression in the endometrium of women with endometriosis and found increased levels in the eutopic tissue.

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Abstract

ObjectiveTo compare the angiogenic activities of endothelial cells in the eutopic endometrium of women with and without endometriosis.DesignVessels with active angiogenesis were identified using the monoclonal antibody to endoglin.SettingUniversity department of obstetrics and gynecology.Patient(s)Twenty women with histologically confirmed endometriosis after laparotomy or laparoscopy. Women with carcinoma in situ of uterine cervix, but no evidence of endometriosis (n = 20), served as control subjects.Intervention(s)Formalin-fixed, paraffin-embedded archival tissues were sectioned and stained.Main outcome measure(s)Number of vessels stained with monoclonal antibody to endoglin.Result(s)For all menstrual phases, the mean number of vessels with endoglin expression was significantly greater in patients with endometriosis compared with control subjects. In each menstrual phase, a significant difference was observed only during the late secretory phase. Within the group with endometriosis, the mean numbers of vessels with endoglin expression in stages I and II were not different from the numbers in stages III and IV.Conclusion(s)This study shows the expression of endoglin in the eutopic endometrium of women with endometriosis is significantly increased and the increase is observed only in the late secretory phase. It is suggested from these findings that activation of angiogenesis in the eutopic endometrium might be a key factor in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Endometrium Vascular Cell Adhesion Molecule-1 Adult Antigens, CD Endoglin Endometriosis Endometriosis Endometrium Endometrium Endometrium Endothelium, Vascular Endothelium, Vascular Female Humans Immunohistochemistry Menstrual Cycle Neovascularization, Pathologic

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (26)

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