Endoglin concentration in peritoneal fluid of patients with endometriosis

Nusratuddin Abdullah
In: Medical Journal of Indonesia · 2013 · pp. 88 · doi:10.13181/mji.v22i2.535 · W2067746003
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Peritoneal fluid endoglin concentrations were higher in women with endometriosis, increasing with disease severity and potentially serving as a predictive factor.

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This observational cross-sectional pilot study measured peritoneal fluid endoglin concentrations by ELISA in patients undergoing laparoscopy for infertility or other indications at hospitals in Makassar, Indonesia, comparing an endometriosis group (staged by ASRM and split into mild vs severe) with controls. Peritoneal endoglin was higher in endometriosis (median 15.04 ng/mL) than in controls (median 8.84 ng/mL), and levels increased with disease severity; the authors report that an endoglin concentration ≥11 ng/mL could predict endometriosis. A key limitation is that it was a small, pilot design with cross-sectional measurements, and the analysis relied on Spearman correlations based on the collected samples. This paper is centrally about endometriosis — it evaluates peritoneal endoglin concentration as a potential diagnostic/predictive marker and assesses its relationship to endometriosis severity.

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Abstract

Background: Endoglin is a specific angiogenic factor suspected to involve in the pathogenesis of endometriosis. The aim of this study was to evaluate the significance of endoglin concentration in the peritoneal fluid of patients with endometriosis. Methods: This pilot study was performed between March 2011 and July 2012 at Dr. Wahidin Sudirohusodo Hospital and another private hospital in Makassar, Indonesia. This was an observational, cross-sectional study. All patients undergoing laparoscopy for infertility and other cases with suitable inclusion criteria were asked to answer a questionnaire and had a 5 cc peritoneal fluid sample taken for measurement of peritoneal endoglin concentration using ELISA. Endometriosis stage was classified using ASRM criteria and divided into two groups, mild and severe. All data were analyed using Excel and Spearman correlation analysis. Results: In the endometriosis group peritoneal endoglin concentration ranged between 14.43- 15.65 ng/mL (median 15.04 ng/mL) which is higher than control group 7.42-10.26 ng/mL (median 8.84 ng/mL). A peritoneal endoglin concentration equal to or higher than 11 ng/mL could be used to predict endometriosis. Conclusion: Endoglin concentrations increased proportionally with the severity of endometriosis, and many be used as predictive factor of endometriosis cases. (Med J Indones. 2013;22:88-91)
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Background

Endoglin is a specific angiogenic factor suspected to involve in the pathogenesis of endometriosis. The aim of this study was to evaluate the significance of endoglin concentration in the peritoneal fluid of patients with endometriosis.

Methods

This pilot study was performed between March 2011 and July 2012 at Dr. Wahidin Sudirohusodo Hospital and another private hospital in Makassar, Indonesia. This was an observational, cross-sectional study. All patients undergoing laparoscopy for infertility and other cases with suitable inclusion criteria were asked to answer a questionnaire and had a 5 cc peritoneal fluid sample taken for measurement of peritoneal endoglin concentration using ELISA. Endometriosis stage was classified using ASRM criteria and divided into two groups, mild and severe. All data were analyed using Excel and Spearman correlation analysis.

Results

In the endometriosis group peritoneal endoglin concentration ranged between 14.43- 15.65 ng/mL (median 15.04 ng/mL) which is higher than control group 7.42-10.26 ng/mL (median 8.84 ng/mL). A peritoneal endoglin concentration equal to or higher than 11 ng/mL could be used to predict endometriosis.

Conclusion

Endoglin concentrations increased proportionally with the severity of endometriosis, and many be used as predictive factor of endometriosis cases. (Med J Indones. 2013;22:88-91) Downloads

References

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