Interleukin-11, IL-11 receptorα and leukemia inhibitory factor are dysregulated in endometrium of infertile women with endometriosis during the implantation window

Evdokia Dimitriadis, Chelsea Stoikos, C. Stoikos, Dimitriadis E, Stoikos C, Martyn A Stafford‐Bell, Martyn Stafford-Bell, Ian A. Clark, Ian Clark, Stafford-Bell M, Clark I, Gábor Kovács, Premila Paiva, Gabor Kovacs, Kovacs G, Lois A. Salamonsen
Journal of Reproductive Immunology · 2005 · vol. 69(1) , pp. 53–64 · doi:10.1016/j.jri.2005.07.004 · PMID:16310857 · W1985233208
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This study investigated the expression of Interleukin-11, IL-11 receptorα, and leukemia inhibitory factor in the endometrium of infertile women with endometriosis during the implantation window and found they were dysregulated.

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Abstract

Interleukin (IL)-11 is essential for embryo implantation in the mouse and evidence suggests it has a role in implantation in humans. This study has evaluated immunoreactive IL-11, IL-11 receptor (R) alpha and leukemia inhibitory factor (LIF) in endometrium of infertile women with endometriosis (I/E) and normal fertile women (controls) during the implantation window. Endometrial biopsies from I/E (N = 7) were timed from the LH surge and were post-ovulatory days (POD) 5-10. Control biopsies (N = 8) from women were between days 19 and 24 of the menstrual cycle. Staining intensity of IL-11, IL-11Ralpha and LIF evaluated using semi-quantitative immunohistochemistry scores. Immunoreactive IL-11, IL-11Ralpha and LIF were present predominantly in glandular epithelium, while luminal epithelium showed patchy staining. All controls stained positively for IL-11, IL-11Ralpha and LIF in glandular epithelium. IL-11 and IL-11Ralpha staining was absent from glandular epithelium in cohorts of I/E. LIF staining intensity in glandular epithelium was significantly lower in I/E compared to controls. The results suggest that reduced endometrial IL-11 and/or LIF may contribute to infertility in some endometriotic women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Infertility, Female Interleukin-11 Interleukin-6 Receptors, Interleukin Adult Embryo Implantation Embryo Implantation Endometriosis Endometrium Endometrium Female Humans Immunohistochemistry Infertility, Female Interleukin-11 Interleukin-11 Receptor alpha Subunit Interleukin-6 Leukemia Inhibitory Factor

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