Endometrial injury for patients with endometriosis and polycystic ovary syndrome undergoing medically assisted reproduction: current data and a protocol

Charalampos Siristatidis, Ioannis Rigos, Vasilios Pergialiotis, Vasilios Karageorgiou, Nikolaos Christoforidis, George Daskalakis, Stefano Bettocchi, Antonis Makrigiannakis
Hormone molecular biology and clinical investigation · 2018 · vol. 35(1) · doi:10.1515/hmbci-2018-0040 · PMID:30144383 · W2890293280
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper proposes a study protocol to investigate whether endometrial injury before medically assisted reproduction improves pregnancy rates in infertile women with endometriosis and polycystic ovary syndrome.

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Abstract

We propose a study protocol capable of improving clinical outcomes following medically assisted reproduction (MAR) in infertile women with endometriosis and polycystic ovary syndrome (PCOS). The proposed research derives from the published evidence on the positive impact from endometrial injury (EI) and the beneficial nature of the intervention towards improved implantation rates. We primarily refer to the cluster of events and hypotheses, such as the mechanical cascade, the inflammatory response per se, the events accompanying wound healing, the immune cell recruitment and protein involvement, alterations in gene expression and the neo-angiogenesis theories, which have been previously investigated for this purpose. We are also exploring the possible problems in MAR cycles with negative outcomes in PCOS and endometriosis patients and we are proposing potential mechanisms on how this intervention might work. Our hypothesis states that the EI before the initiation of the MAR cycle can affect clinical pregnancy rates in patients with the aforementioned pathologies.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Infertility, Female Polycystic Ovary Syndrome Reproductive Techniques, Assisted Adult Endometriosis Endometriosis Endometrium Endometrium Female Humans Infertility, Female Infertility, Female Ovulation Induction Ovulation Induction Polycystic Ovary Syndrome Polycystic Ovary Syndrome Pregnancy Pregnancy Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (57)

Cited by (1)

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